Experimental treatments of endometriosis

Attar R, Rukset Attar, Rükset Attar, Attar E, Erkut Attar
Women's health (London, England) · 2015 · vol. 11(5) , pp. 653–664 · doi:10.2217/whe.15.51 · PMID:26314760 · W2218042931
Review OA: gold CC0 ⤵ 6 in-corpus citations
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This review summarizes novel experimental treatments for endometriosis, an estrogen-dependent disease, focusing on molecular targets to improve upon current therapies with significant side effects and limited efficacy for infertility.

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Abstract

Endometriosis is defined as the presence of endometrial gland and stroma outside the uterine cavity. It is an estrogen-dependent disease and is associated with chronic pelvic pain, dysmenorrhea, dyspareunia and infertility. The treatment of endometriosis is conservative or radical surgery, medical therapies or their combination. All currently used hormonally active treatments are effective in the treatment of endometriosis; however, the adverse effects of these hormonal treatments limit their long-term use. Moreover, recurrence rates are high after cessation of therapy, and the treatments have no benefit in endometriosis-associated infertility. Therefore, researchers are working on new treatment modalities with improved side effects, mainly focusing on the molecular targets involved in etiopathogenesis of endometriosis. Here we summarized these novel treatments modalities.

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Condition tags

endometriosischronic_pelvic_paindysmenorrheadyspareuniainfertility

MeSH descriptors

Drugs, Investigational Endometriosis Infertility, Female Therapies, Investigational Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Drugs, Investigational Drugs, Investigational Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Fertility Fertility Fertility

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (91)

Cited by (7)

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