Analysis of p53 and ras gene mutations in endometriosis
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Analysis of 10 women with severe endometriosis found no activating ras gene mutations or inactivating p53 tumor suppressor gene mutations in eutopic or ectopic endometrium.
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Abstract
No activating mutations in codons 12, 13 and 61 of ras genes nor inactivating mutations in exons 5-9 of the p53 tumor suppressor gene were detected by polymerase chain reaction and single-strand conformation polymorphism methods in either eutopic or ectopic endometrium from 10 women with severe endometriosis.
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References (2)
- Endometriosis and ovarian cancer via openalex
- W2031756680 via openalex
Cited by (29)
- Polymorphisms and endometriosis: a systematic review and meta-analyses 2019
- Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis 2018
- The codon 72 polymorphism of the TP53 gene and endometriosis risk: a meta-analysis 2015
- Endometriosis and ovarian cancer: potential benefits and harms of screening and risk-reducing surgery 2015
- Endometriosis‐Associated Ovarian Cancer 2014
- K-Ras 4A Transcript variant is up-regulated in eutopic endometrium of endometriosis patients during proliferative phase of menstrual cycle 2014
- TP53 gene polymorphisms at codons 11, 72, and 248 and association with endometriosis in a Brazilian population 2014
- [Endometriosis-associated ovarian cancers: pathogenesis and consequences on daily practice] 2013
- A polymorphism in a let-7 microRNA binding site of KRAS in women with endometriosis 2012
- Association of p53 and CDKN1A genotypes with endometriosis 2011
- Hibridação Genômica Comparativa em Endometriose 2008
- Bias versus causality: interpreting recent evidence of association between endometriosis and ovarian cancer 2007
- Endometriosis and genetic polymorphisms 2007
- P53 codon 11, 72, and 248 gene polymorphisms in endometriosis 2006
- Nuclear factor-kappab (NF-kappaB): an unsuspected major culprit in the pathogenesis of endometriosis that is still at large? 2006
- Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriosis: a critical analysis 2005
- Quantitative DNA perturbations of p53 in endometriosis: analysis of American and Icelandic cases 2005
- Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer 2004
- Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer 2004
- Analysis of the codon 72 polymorphism of the TP53 gene in patients with endometriosis 2004
- Pathology of Non-Neoplastic Ovarian Enlargements 2003
- The proline form of p53 codon 72 polymorphism is associated with endometriosis 2002
- Somatic DNA alterations in endometriosis: high frequency of chromosome 17 and p53 loss in late-stage endometriosis 2002
- Heritability and molecular genetic studies of endometriosis 2002
- Comparative immunohistochemical studies of bcl-2 and p53 proteins in benign and malignant ovarian endometriotic cysts 2002
- Heritability and molecular genetic studies of endometriosis 2002
- Endometriosis: candidate genes 2001
- Biases in the endometriosis literature. Illustrated by 20 years of endometriosis research in Leuven 1998
- Detection of chromosomal aneuploidy in endometriosis by multi-color fluorescence in situ hybridization (FISH) 1997
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- europepmc
- last seen: 2026-10-13T06:10:10.580696+00:00
- openalex
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- pubmed
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- unpaywall
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