Endometriosis and Infertility: The Role of Oxidative Stress

Ionara Diniz Evangelista Santos Barcelos, Paula Andrea Navarro
In: Endometriosis - Basic Concepts and Current Research Trends · 2012 · doi:10.5772/31406 · W1604994019
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Reactive oxygen species, generated through cellular respiration and other reactions, play a role in both normal reproductive function and pathological conditions like endometriosis, potentially causing DNA damage.

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Abstract

The ROS have physiological and pathological functions in the female reproductive tract. Fertility problems related to ROS have etiopathogenic factors in common These reactive species are generated through enzymatic and non-enzymatic organic reactions. Biological reactions, through electron transference or through oxigenase, that use www.intechopen.com Endometriosis -Basic Concepts and Current Research Trends 400 oxygen (O 2 ) as substrate, generate large amounts of ROS. As the mithocondrial respiratory chain is the major O 2 cell intake system, the majority of ROS are produced by this system under physiological conditions The superoxide radical (O 2 -) is formed when electrons leak from the electron transport chain (O 2 + e - O 2 -) The dismutation of superoxide results in the formation of hydrogen peroxide ( et al., 2005). The same can also be generated by reduction of O 2 -(O 2 -+ e -+ 2 H + H 2 O 2 ) The hidroxyl (OH -) ion is formed by the acquisition of 1 electron by H 2 O 2 (H 2 O 2 + e-+ H + OH + H 2 O) The hydroxyl ion is highly reactive and can modify purines and pyrimidines and cause strand breaks resulting in DNA damage

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endometriosisinfertility

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