Luteinized unruptured follicle syndrome in mild endometriosis. Assessment with biochemical parameters.

Gary Holtz, G Holtz, Williamson Ho, H O Williamson, Mathur Rs, R S Mathur, Landgrebe Sc, S C Landgrebe, Moore Ee, E E Moore
The Journal of reproductive medicine · 1985 · vol. 30(9) , pp. 643–5 · PMID:4057180 · W2435097537
article OA: closed CC0 ⤵ 14 in-corpus citations
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This study assessed biochemical parameters in women with mild endometriosis and found evidence suggesting luteinized unruptured follicle syndrome occurs occasionally, with impaired ovarian steroidogenesis also frequently observed.

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Abstract

Failure to extrude an ovum, with subsequent luteinization of the unruptured follicle (LUF), has been proposed as a cause of infertility in women with mild endometriosis. To assess the incidence of this process we performed laparoscopies in the early luteal phase on 16 women with mild endometriosis and 8 control subjects. Peritoneal fluid was aspirated and a plasma sample obtained concurrently. Estradiol (E2) and progesterone (P) concentrations were determined. A review of the literature suggested that the following hormonal criteria correlated with follicular rupture: fluid E2 greater than or equal to 500 pg/ml, E2 fluid/plasma ratio greater than or equal to 3.1, fluid P greater than or equal to 3,000 ng/dl and P fluid/plasma ratio greater than or equal to 5:1. All control subjects met at least one E2 and one P criterion: 75% met all. In contrast, less than one-third with mild endometriosis met all, and three (19%) met none. Five met only E2 criteria. These findings suggest that LUF occurs occasionally in association with mild endometriosis. Additionally, ovarian steroidogenesis, particularly P secretion, was impaired frequently in the absence of LUF in women with endometriosis.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Luteal Phase Ovarian Diseases Ovarian Follicle Ascitic Fluid Endometriosis Estradiol Estradiol Female Humans Ovarian Diseases Ovarian Follicle Progesterone Progesterone

Citation neighborhood

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Cited by (14)

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