The presence of luteinized unruptured follicle syndrome and altered folliculogenesis in rats with surgically induced endometriosis

Moon CE, Carol Eve M. Moon, C E Moon, Bertero MC, Maria C. Bertero, M C Bertero, Curry TE, Thomas E. Curry, T E Curry, London SN, S N London, Steven N. London, Ken Muse, K N Muse, Muse KN, Sharpe KL, Kathy L. Sharpe, K L Sharpe, M W Vernon, Michael W. Vernon, Vernon MW
American journal of obstetrics and gynecology · 1993 · vol. 169(3) , pp. 676–682 · doi:10.1016/0002-9378(93)90642-v · PMID:8372879 · W2054525378
article OA: closed CC0 ⤵ 26 in-corpus citations
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This study investigated the luteinized unruptured follicle syndrome and altered folliculogenesis in rats that underwent surgically induced endometriosis.

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Abstract

ObjectiveOur purpose was to determine in the rat model whether endometriosis could influence ovarian function by altering oocyte release or folliculogenesis.Study designWe histologically examined the ovaries of reproductively cycling rats with (n = 16) and without (n = 10) surgically induced endometriosis. The rats in these two groups were further subdivided into unilaterally ovariectomized or ovarian-intact groups. Serial sections of ovaries were examined, and follicular development and frequency of luteinized unruptured follicles were determined.ResultsA significant tenfold increase in the number of luteinized unruptured follicles was observed in the ovaries from rats with endometriosis (2.7 per rat) compared with unoperated and sham-operated control groups (overall mean 0.26 per rat, p < 0.05). Additionally, ovaries from unilateral ovariectomized animals with endometriosis contained four times as many luteinized unruptured follicles (four per rat) as did the ovaries from bilaterally ovarian-intact rats with endometriosis (1.40 per rat, p < 0.01). Fewer follicles were present in rats with endometriosis (180 follicles per ovary) than in control rats (231 follicles per ovary, p < 0.05).ConclusionIn the rat model the presence of ectopic endometrium is associated with an increased frequency of luteinized unruptured follicles and altered follicular development.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Infertility, Female Ovarian Follicle Animals Corpus Luteum Corpus Luteum Disease Models, Animal Endometriosis Endometriosis Endometriosis Female Infertility, Female Luteal Phase Ovarian Follicle Ovarian Follicle Progesterone Progesterone Rats Rats, Sprague-Dawley Syndrome

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (20)

Cited by (26)

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