Evaluation of erythrocyte band 3 phosphotyrosine level, glutathione content, CA-125, and human epididymal secretory protein E4 as combined parameters in endometriosis

Luciana Bordin, Cristina Fiore, Fiore C, Donà G, Gabriella Donà, Alessandra Andrisani, Ambrosini G, Guido Ambrosini, Faggian D, Diego Faggian, Mario Plebani, Plebani M, Giulio Clari, Clari G, Decio Armanini
Fertility and sterility · 2010 · vol. 94(5) , pp. 1616–1621 · doi:10.1016/j.fertnstert.2009.10.038 · PMID:20153468 · W2047226637
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This study evaluated erythrocyte band 3 phosphotyrosine level, glutathione content, CA-125, and human epididymal secretory protein E4 as combined diagnostic parameters for endometriosis.

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Abstract

OBJECTIVE: To investigate the biochemical parameters of the erythrocyte response to diamide-induced oxidative stress, alone or as adjuncts to serum values of CA-125 and human epididymal secretory protein E4 (HE4), in the diagnosis and study of endometriosis. SETTING: University of Padova. DESIGN: Prospective study. PATIENT(S): Forty-five patients of reproductive age undergoing laparoscopy. INTERVENTION(S): All women were studied for endometriotic foci during laparoscopic surgery. Forty-one had laparoscopically and histologically confirmed endometriosis, and four did not. Twenty women with confirmed endometriosis were reassessed 1-4 months later. MAIN OUTCOME MEASURE(S): CA-125 and HE4 and two new parameters evaluated in erythrocytes after diamide-induced stress, that is, band 3 tyrosine phosphorylation (Tyr-P) level and decrease in total glutathione content (ΔGSH), were assessed in all patients. RESULT(S): In association with serum CA-125 levels but not with HE4, diamide-related erythrocyte band 3 Tyr-P and ΔGSH were significantly higher in patients with endometriosis and were able to discriminate with high sensitivity and specificity between patients before and after surgery. CONCLUSION(S): Endometriosis is associated with an increase in systemic oxidative stress, affecting the antioxidative defenses of circulating erythrocytes. All related implications, including evaluation of other oxidative stress-related changes, warrant further study.

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Condition tags

endometriosis

MeSH descriptors

Anion Exchange Protein 1, Erythrocyte Anion Exchange Protein 1, Erythrocyte CA-125 Antigen Endometriosis Epididymal Secretory Proteins Erythrocytes Glutathione Phosphotyrosine Uterine Diseases Adult Adult beta-Defensins beta-Defensins Biomarkers Biomarkers Biomarkers CA-125 Antigen CA-125 Antigen Case-Control Studies Case-Control Studies

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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