Aromatase in endometriosis and uterine leiomyomata

Serdar E. Bulun, Bulun Se, Imir G, Gonca İmir, Utsunomiya H, Hiroki Utsunomiya, Thung S, Steven Thung, Gurates B, Bilgin Gurates, Bilgin Gürateş, Tamura M, Mitsutoshi Tamura, Zhihong Lin, Lin Z
The Journal of steroid biochemistry and molecular biology · 2005 · vol. 95(1-5) , pp. 57–62 · doi:10.1016/j.jsbmb.2005.04.012 · PMID:16024248 · W2119512564
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This paper investigates the role and expression of aromatase in endometriosis and uterine leiomyomata tissues.

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Abstract

Endometrial tissue from uterine disease-free women does not exhibit aromatase activity. In contrast, aromatase enzyme activity and mRNA levels are readily detectable in endometriosis. PGE2 stimulates both aromatase expression and activity in endometriotic stromal cells via promoter II region of the aromatase gene. This results in local production of estradiol, which induces PGE2 formation and establishes a positive feedback cycle. This mechanism seems to contribute to continuous production of estradiol and PGE2. Aromatase mRNA levels and enzyme activity are also present in uterine leiomyomata that are estrogen-dependent benign tumors of the myometrium. Successful treatment of endometriosis and uterine leiomyomata using aromatase inhibitors by recent pilot trials underscores the clinical significance of these molecular studies.

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Condition tags

endometriosis

MeSH descriptors

Aromatase Endometriosis Leiomyoma Uterine Neoplasms Aromatase Aromatase Aromatase Aromatase Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Endometriosis Endometriosis Endometriosis Estrogens Estrogens Estrogens Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (47)

Cited by (50)

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