Steven Thung

No ORCID on file · 4 papers in corpus
article 2007
Upstream Stimulatory Factor-2 Regulates Steroidogenic Factor-1 Expression in Endometriosis
Molecular endocrinology (Baltimore, Md.) ·doi:10.1210/me.2006-0302

Local estrogen biosynthesis is a major factor in the pathogenesis of endometriosis. Aberrant expression of steroidogenic acute regulatory protein (StAR) and aromatase in endometriotic tissue leads to an up-regulation of estrogen production.…

review 2005
Aromatase in endometriosis and uterine leiomyomata
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2005.04.012

Endometrial tissue from uterine disease-free women does not exhibit aromatase activity. In contrast, aromatase enzyme activity and mRNA levels are readily detectable in endometriosis. PGE2 stimulates both aromatase expression and activity i…

article 2005
Defect of Stroma-Epithelial Interaction in Endometriosis is Responsible for Lack of Induction of 17β-Hydroxsteroid Dehydrogenase Type 2 by Progesterone
·doi:10.1016/j.fertnstert.2005.07.469
review 2005
Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment
Pharmacological reviews ·doi:10.1124/pr.57.3.6

A single gene encodes the key enzyme for estrogen biosynthesis termed aromatase, inhibition of which effectively eliminates estrogen production. Aromatase inhibitors successfully treat breast cancer and endometriosis, whereas their roles in…