Transferrin receptor (CD71) expression in peritoneal macrophages from fertile and infertile women with and without endometriosis

Sergio Martínez‐Román, Martínez-Román S, S Martínez-Román, Balasch J, Juan Balasch, J Balasch, Montserrat Creus, M Creus, Creus M, F Fábregues, Fábregues F, Francisco Fábregues, F Carmona, Francisco Carmona, Vilella R, R. Vilella, Juan A. Vanrell, Vanrell JA, J A Vanrell
American journal of reproductive immunology (New York, N.Y. : 1989) · 1997 · vol. 38(6) , pp. 413–417 · doi:10.1111/j.1600-0897.1997.tb00320.x · PMID:9412724 · W2046888386
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Peritoneal macrophages from infertile women with endometriosis exhibited significantly increased transferrin receptor (CD71) expression compared to three control groups.

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Abstract

PROBLEM: Hyperactivated macrophages are implicated in the pathophysiology of endometriosis-associated infertility. This study investigates transferrin receptor expression (CD71) as a marker of hyperactivity in peritoneal macrophages of infertile patients with minimal to mild endometriosis (group 1, n = 25). METHOD OF STUDY: Expression of the activation antigen CD71 on peritoneal fluid macrophages was determined by a specific monoclonal anti-CD71 antibody using indirect immunofluorescence technique and was analyzed by flow cytometry. Three different control groups of women were used: women with unexplained infertility (group 2, n = 25), fertile women with endometriosis (group 3, n = 10), and fertile women without endometriosis (group 4, n = 25). RESULTS: The percentage of CD71 positive cells was significantly increased in infertile women with endometriosis as compared with the three control groups. There were no differences among groups 2, 3, and 4 with respect to the percentage of CD71 positive macrophages. CONCLUSIONS: Our results favor the concept that hyperactivated macrophages play a role in the pathophysiology of endometriosis-associated subfertility, a feature which is lacking in patients with unexplained infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Macrophages, Peritoneal Receptors, Transferrin Adult Adult Endometriosis Endometriosis Female Female Humans Humans Infertility, Female Infertility, Female Macrophage Activation Macrophage Activation Macrophages, Peritoneal Macrophages, Peritoneal Macrophages, Peritoneal Receptors, Transferrin

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