Pituitary-ovarian function in women with minimal or mild endometriosis and otherwise unexplained infertility
Observational
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CC0
⤵ 21 in-corpus citations
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This study compared pituitary-ovarian function in women with minimal/mild endometriosis and infertility to fertile controls, finding dysfunction in 82% of study cycles.
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Abstract
OBJECTIVE: To determine whether abnormalities of pituitary-ovarian function are associated with minor degrees of endometriosis in women with otherwise unexplained infertility.
DESIGN: Comparison of pituitary-ovarian function in a group of 22 patients with that in a control group of 10 healthy fertile women.
PATIENTS: Twenty-two women with minimal or mild endometriosis and otherwise unexplained infertility.
MEASUREMENTS: Ovarian ultrasound and radioimmunoassay of pituitary and ovarian hormones.
RESULTS: Abnormalities, including luteinization of unruptured follicles, broad LH surges and low concentrations of progesterone during the luteal phase, were demonstrated in 82% of study cycles.
CONCLUSION: Pituitary-ovarian dysfunction appears to be associated with minimal or mild endometriosis in women with otherwise unexplained infertility but the diversity of endocrine abnormalities demonstrated suggests that endometriosis is unlikely to be an aetiological factor in their development.
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References (20)
- Alterations in progesterone metabolism and luteal function in infertile women with endometriosis via openalex
- A study of plasma progesterone, oestradiol-17beta, prolactin and LH levels, and of the luteal phase appearance of the ovaries in patients with endometriosis and infertility via openalex
- Cyclical gonadotrophin and progesterone secretion in women with minimal endometriosis via openalex
- Direct 125I-radioligand assays for serum progesterone compared with assays involving extraction of serum via openalex
- Follicle growth patterns and endocrinological abnormalities in infertile women with minor degrees of endometriosis via openalex
- Gonadotrophin responses to oestrogen provocation in women with minimal endometriosis via openalex
- Linear regression analysis of ultrasound follicular growth series: evidence for an abnormality of follicular growth in endometriosis patients via openalex
- Luteinizing hormone receptor disorder in endometriosis via openalex
- Mild endometriosis and ovulatory dysfunction: effect of danazol treatment on success of ovulation induction via openalex
- New aspects of the pathophysiology of endometriosis and associated infertility via openalex
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Cited by (22)
- Beyond the surface: Does stage I-II endometriosis impact fertility? Exploring the challenges of mild disease 2024
- Identifying Mechanisms of Endometriosis-Associated Reduced Fecundity in a Rat Model: Novel Insights toward Understanding Human Infertility 2020
- Serum anti-Mullerian hormone, prolactin and estradiol concentrations in infertile women with endometriosis 2020
- Clinical and endocrine features of Brazilian infertile women with or without endometriosis: A comparative cross-sectional study 2014
- Anatomy, Development, Histology, and Normal Function of the Ovary 2014
- Endometriosis and ART 2012
- Cellular and molecular basis for endometriosis-associated infertility 2012
- Infertilidad y endometriosis 2007
- Endometriosis and Infertility: A Causal or Casual Role? 2006
- Endometriosis and inflammation in infertility 2004
- Endometriosis and inflammation in infertility 2004
- Pre-ovulatory granulosa cells of infertile women with endometriosis are less sensitive to luteinizing hormone 2003
- An evidence-based evaluation of endometriosis-associated infertility 2003
- Physiopathological aspects of corpus luteum defect in infertile patients with mild/minimal endometriosis 2003
- Total cortisol levels are reduced in the periovulatory follicle of infertile women with minimal-mild endometriosis 2002
- Role of laparoscopy in the treatment of endometriosis-associated infertility 2002
- Endometriosis and infertility: the debate continues 2002
- What is the optimal medical management of infertility and minor endometriosis? Analysis and future prospects 2002
- Endometriosis: an overview of the disease and its treatment 2000
- Pituitary-ovarian dysfunction and endometriosis 2000
- Pathophysiology of endometriosis-associated infertility 1999
- Pituitary-ovarian dysfunction as a cause for endometriosis-associated and unexplained infertility 1995
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- europepmc
- last seen: 2026-10-18T06:15:09.303036+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:02:56.066688+00:00
- unpaywall
- last seen: 2026-10-18T06:28:46.490043+00:00
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