Danazol: endocrine consequences in healthy women
Non-randomised trial
OA: closed
CC0
⤵ 24 in-corpus citations
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This paper investigates the endocrine effects of danazol treatment in healthy women.
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Abstract
We studied the effects of danazol on pituitary and gonadal function in seven normal women who volunteered to take danazol, 400 mg twice daily, for 2 months. We measured circulating levels of sex steroids, gonadotropins, and prolactin on alternate days throughout a control menstrual cycle and during treatment. Danazol inhibited ovulation in all subjects. The amenorrheic state induced by danazol was characterized by normal basal levels of gonadotropins, prolactin, and estrogen. Serum androgen levels were significantly increased as was the urinary excretion of 17-ketosteroids. The LH and FSH responses to gonadotropin-releasing hormone were enhanced during treatment, and there was a normal LH rise following administration of estradiol valerate, indicative of intact positive feedback. These observations fail to support the contention that danazol suppresses pituitary gonadotropin secretion or directly inhibits steroidogenesis. The results suggest that danazol may have a primary site of action at the ovary by suppressing the normal, orderly process of follicular maturation.
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References (14)
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- Evidence that danazol inhibits gonadotropin-induced ovarian steroidogenesis at a point distal to gonadotropin-receptor interaction and adenosine 3',5' cyclic monophosphate formation via openalex
- Hormonal changes associated with Danazol therapy via openalex
- Hormonal, metabolic and clinical effects of danazol in the treatment of endometriosis via openalex
- Mechanism of induction of luteal phase defects by danazol via openalex
- Pituitary gonadotropin responsiveness with danazol via openalex
- Sex steroid levels during treatment of endometriosis via openalex
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Cited by (24)
- Medical management of endometriosis 2021
- Danazol treatment of endometriosis-associated pain 2006
- Danazol influences gonadotropin secretion acting at the hypothalamic level 1994
- Danazol in autoimmune haemolytic anaemia 1993
- Endometriosis—the role of medroxyprogesterone acetate 1992
- Medical treatment of mild endometriosis associated with infertility 1991
- Thermoregulatory and endocrine effects of a low dose of danazol in postmenopausal women: interaction with the effect of naloxone 1991
- Treatment of laparoscopically confirmed endometriosis with danazol 1989
- Endocrine, metabolic, and clinical effects of gestrinone in women with endometriosis 1989
- Hormonal therapy of endometriosis 1989
- Prolactin and its response to the luteinizing hormone-releasing hormone thyrotropin-releasing hormone test in patients with endometriosis before, during, and after treatment with danazol 1989
- The treatment of glucocorticosteroid-dependent chronic urticaria with stanozolol 1988
- Endometriosis 1987
- Dosage-related effects of danazol on sex hormone binding globulin and free and total androgen levels 1986
- Inhibitory effects of danazol on steroidogenesis in cultured human granulosa cells 1986
- Endocrine consequences of danazol treatment in menorrhagia 1986
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1985
- Endometriosis 1985
- Profound alterations of the lipoprotein metabolism during danazol treatment in premenopausal women 1984
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1984
- The influence of danazol on pituitary function and on the ovarian follicular hormone secretion in premenopausal women 1984
- Endocrine effects of danazol in the treatment of endometriosis 1984
- The effect of danazol on gonadotropin secretion during the follicular phase of the menstrual cycle 1983
- Effects of danazol on plasma lipid and lipoprotein levels in healthy women and in women with endometriosis 1983
Source provenance
- openalex
- last seen: 2026-05-14T05:57:23.665459+00:00
- pubmed
- last seen: 2026-10-08T21:58:26.348914+00:00
- unpaywall
- last seen: 2026-10-15T06:24:24.424788+00:00
License: CC0
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