Danazol influences gonadotropin secretion acting at the hypothalamic level

Dimitrios Panidis; D Panidis; D Vavilis; Dimitrios Vavilis; D Rousso; K Stergiopoulos; Andreas P. Kalogeropoulos; A Kalogeropoulos

doi:10.1016/0020-7292(94)90249-6

Danazol influences gonadotropin secretion acting at the hypothalamic level

Dimitrios Panidis, D Panidis, D Vavilis, Dimitrios Vavilis, D Rousso, K Stergiopoulos, Andreas P. Kalogeropoulos, A Kalogeropoulos

International Journal of Gynecology & Obstetrics · 1994 · vol. 45(3) , pp. 241–246 · doi:10.1016/0020-7292(94)90249-6 · PMID:7926243 · W2060506337

article OA: closed CC0 ⤵ 2 in-corpus citations

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Danazol treatment in women with endometriosis significantly increased GnRH-stimulated gonadotropin response but suppressed LH response to clomiphene citrate, suggesting hypothalamic action.

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Abstract

OBJECTIVES: The purpose of the study was to determine the influence of danazol on gonadotropin secretion. METHODS: Ten endometriotic patients were treated with danazol for 6 months. To evaluate gonadotropin and estradiol secretion, a gonadotropin-releasing hormone (GnRH) test and a clomiphene citrate (CC) challenge test were carried out in the follicular phase before treatment, during the sixth month of treatment and after the reappearance of the second menses. The same tests were also performed, only once, in the follicular phase of ten normal women. RESULTS: GnRH-stimulated gonadotropin response during danazol treatment was significantly higher than that in the same group of women before and after danazol treatment, as well as in controls. Gonadotropin increase after clomiphene citrate administration during danazol treatment was not significant; moreover, LH response was significantly lower than that in the same group of patients before and after danazol treatment, as well as in controls. CONCLUSIONS: Our results suggest that danazol exerts a suppressive effect on gonadotropin secretion acting at the hypothalamic level.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Gonadotropins Hypothalamus Adult Danazol Danazol Endometriosis Endometriosis Female Gonadotropins Humans Hypothalamus Hypothalamus

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References (15)

Changes of Prolactin Secretion Following Long-Term Danazol Application via openalex
Clinical Studies with an Antigonadotropin-Danazol via openalex
Danazol: Endocrine consequences in healthy women via openalex
Danazol inhibits steroidogenesis by the human ovary in vivo via openalex
Dynamic tests of hypothalamic and pituitary function in women treated with danazol via openalex
Effects of danazol on pulsatile gonadotropin patterns and on serum estradiol levels in normally cycling women via openalex
Inhibitory effects of danazol on steroidogenesis in cultured human granulosa cells via openalex
Placebo-controlled comparison of hormonal and biochemical effects of danazol and high-dose medroxyprogesterone acetate via openalex
SHBG-Serumspiegel bei Frauen mit Endometriose vor, während und nach Danazol-Langzeittherapie via openalex
The effect of danazol on gonadotropin secretion during the follicular phase of the menstrual cycle via openalex
The effect of danazol on pulsatile gonadotropin secretion in women with endometriosis via openalex
The influence of danazol on pituitary function and on the ovarian follicular hormone secretion in premenopausal women via openalex
doi:10.1016/s0015-0282(16)48430-x via openalex
W2061541231 via openalex
doi:10.1016/0002-9378(81)90611-6 via openalex

Cited by (2)

Danazol for uterine fibroids 2009
Danazol for uterine fibroids 2009

Source provenance

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License: CC0 · commercial use OK

[1] Changes of Prolactin Secretion Following Long-Term Danazol Application via openalex

[2] Clinical Studies with an Antigonadotropin-Danazol via openalex

[3] Danazol: Endocrine consequences in healthy women via openalex

[4] Danazol inhibits steroidogenesis by the human ovary in vivo via openalex

[5] Dynamic tests of hypothalamic and pituitary function in women treated with danazol via openalex

[6] Effects of danazol on pulsatile gonadotropin patterns and on serum estradiol levels in normally cycling women via openalex

[7] Inhibitory effects of danazol on steroidogenesis in cultured human granulosa cells via openalex

[8] Placebo-controlled comparison of hormonal and biochemical effects of danazol and high-dose medroxyprogesterone acetate via openalex

[9] SHBG-Serumspiegel bei Frauen mit Endometriose vor, während und nach Danazol-Langzeittherapie via openalex

[10] The effect of danazol on gonadotropin secretion during the follicular phase of the menstrual cycle via openalex

[11] The effect of danazol on pulsatile gonadotropin secretion in women with endometriosis via openalex

[12] The influence of danazol on pituitary function and on the ovarian follicular hormone secretion in premenopausal women via openalex

[13] doi:10.1016/s0015-0282(16)48430-x via openalex

[14] W2061541231 via openalex

[15] doi:10.1016/0002-9378(81)90611-6 via openalex