Danazol influences gonadotropin secretion acting at the hypothalamic level

Panidis D, D Panidis, Dimitrios Panidis, Vavilis D, Dimitrios Vavilis, D Vavilis, Rousso D, D. Rousso, Stergiopoulos K, K. Stergiopoulos, Andreas P. Kalogeropoulos, Kalogeropoulos A, A Kalogeropoulos
International Journal of Gynecology & Obstetrics · 1994 · vol. 45(3) , pp. 241–246 · doi:10.1016/0020-7292(94)90249-6 · PMID:7926243 · W2060506337
Non-randomised trial OA: closed CC0 ⤵ 2 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

Danazol treatment in women with endometriosis significantly increased GnRH-stimulated gonadotropin response but suppressed LH response to clomiphene citrate, suggesting hypothalamic action.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVES: The purpose of the study was to determine the influence of danazol on gonadotropin secretion. METHODS: Ten endometriotic patients were treated with danazol for 6 months. To evaluate gonadotropin and estradiol secretion, a gonadotropin-releasing hormone (GnRH) test and a clomiphene citrate (CC) challenge test were carried out in the follicular phase before treatment, during the sixth month of treatment and after the reappearance of the second menses. The same tests were also performed, only once, in the follicular phase of ten normal women. RESULTS: GnRH-stimulated gonadotropin response during danazol treatment was significantly higher than that in the same group of women before and after danazol treatment, as well as in controls. Gonadotropin increase after clomiphene citrate administration during danazol treatment was not significant; moreover, LH response was significantly lower than that in the same group of patients before and after danazol treatment, as well as in controls. CONCLUSIONS: Our results suggest that danazol exerts a suppressive effect on gonadotropin secretion acting at the hypothalamic level.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Gonadotropins Hypothalamus Adult Adult Danazol Danazol Danazol Endometriosis Endometriosis Endometriosis Female Female Gonadotropins Gonadotropins Humans Humans Hypothalamus Hypothalamus

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (15)

Cited by (2)

Source provenance

europepmc
last seen: 2026-10-11T09:27:45.537177+00:00
openalex
last seen: 2026-05-11T07:47:50.945113+00:00
pubmed
last seen: 2026-10-08T21:59:07.256998+00:00
License: CC0 · commercial use OK