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This study evaluated sex hormone binding globulin (SHBG) levels in ten women with endometriosis before, during, and after a six-month course of danazol therapy, comparing them to ten healthy controls. The results indicated that baseline SHBG concentrations were significantly higher in the endometriosis group than in controls, and treatment with danazol caused a significant reduction in these levels. Although SHBG levels remained lower three months post-treatment compared to baseline, they eventually normalized to values similar to those of the control group, suggesting a potential link between SHBG dysregulation and infertility associated with the disease. This paper is centrally about endometriosis — specifically examining hormonal markers and the effects of danazol therapy on SHBG levels in affected patients.
Abstract
Ten patients with endometriosis, aged from 21 to 37 years, were treated with danazol at a dosage level of 200 mg three times daily for 6 months. Three blood samples were drawn 60 min apart for evaluation of the sex hormone binding globulin (SHBG), before danazol administration (4th day of the cycle), during the last two weeks of the six-month therapy and three months after the cessation of treatment (4th day of the cycle). In contrast to that, SHBG levels were also evaluated in ten normal women, aged 21-37 years (4th day of the cycle). It was found that: a) SHGB values were significantly higher in patients with endometriosis than in the control group (p < 0.01), b) danazol resulted in significant decrease of SHBG levels (p < 0.001), c) there was no correlation between SHBG levels before and during danazol administration, and d) SHBG levels were significantly lower three months after the cessation of danazol than before the administration of the medication (p < 0.05), while these levels were not significantly different, compared with those of normal women. Our results support the view, that SHBG production disturbances might interfere with the possible pathogenetic mechanisms of infertility observed in endometriosis.
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DOI: 10.1055/s-2007-1023649
SHBG-Serumspiegel bei Frauen mit Endometriose vor, während und nach Danazol-Langzeittherapie
SHBG Serum Levels in Women with Endometriosis Before, During and After Long-Term Danazol TreatmentPublication History
Publication Date:
18 March 2008 (online)
Zusammenfassung
Die vorliegende Studie wurde in der 3. Gynäkologisch-Geburtshilflichen Abteilung der Aristoteles Universität Thessaloniki/Griechenland ausgeführt und umfaßte 10 Patientinnen mit Endometriose (Untersuchungskollektiv), im Alter von 21-37, sowie 10 Frauen ohne Endometriose (Kontrollen), im Alter von 21-36; die ersteren wurden einer 6monatigen Danazolbehandlung unterzogen. Bei allen Frauen wurden die SHBG- Spiegel mittels 3 Blutentnahmen in 60minütigem Abstand bestimmt. Die Blutentnahmen erfolgten im Kontrollkollektiv am 4. Zyklustag und im Untersuchungskollektiv vor (am 4. Zyklustag), während der letzten 2 Wochen sowie nach der Danazoltherapie (3 Monate danach, am 4. Zyklustag). Unsere Befunde waren wie folgt: a) Die SHBG-Spiegel waren bei den Endometriosepatientinnen signifikant höher als bei den Kontrollen (p< 0,01); b) Danazol führte zu einem signifikanten Absinken der SHBG-Spiegel (p < 0,001); c) es ergab sich keine Korrelation zwischen den SHBG-Spiegeln vor und denjenigen unter der Therapie; d) die SHBG-Konzentrationen waren 3 Monate nach Therapieende signifikant niedriger als vor Therapiebeginn (p < 0,05), sie unterschieden sich jedoch unwesentlich von den bei den Kontrollen ermittelten Werten. Unsere Ergebnisse unterstützen die Ansicht, daß SHBG-Synthesestörungen möglicherweise zu dem pathogenetischen Mechanismus gehören, der bei Endometriose zu Infertilität führen kann.
Abstract
Ten patients with endometriosis, aged from 21 to 37 years, were treated with danazol at a dosage level of 200 mg three times daily for 6 months. Three blood samples were drawn 60 min apart for evaluation of the sex hormone binding globulin (SHBG), before danazol administration (4th day of the cycle), during the last two weeks of the six-month therapy and three months after the cessation of treatment (4th day of the cycle). In contrast to that, SHBG levels were also evaluated in ten normal women, aged 21-37 years (4th day of the cycle). It was found that: a) SHGB values were significantly higher in patients with endometriosis than in the control group (p < 0.01), b) danazol resulted in significant decrease of SHBG levels (p < 0.001), c) there was no correlation between SHBG levels before and during danazol administration, and d) SHBG levels were significantly lower three months after the cessation of danazol than before the administration of the medication (p<0.05), while these levels were not significantly different, compared with those of normal women. Our results support the view, that SHBG production disturbances might interfere with the possible pathogenetic mechanisms of infertility observed in endometriosis.
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