Systematic review and meta-analysis of reproductive outcomes after high-intensity focused ultrasound (HIFU) treatment of adenomyosis

Chen Y, Yi-Shan Chen, Yishan Chen, Shunhe Lin, Lin S, Xie X, Xi Xie, Jingsong Yi, Yi J, Xishi Liu, Liu X, Sun‐Wei Guo, Sun-Wei Guo, Guo SW
Best practice & research. Clinical obstetrics & gynaecology · 2023 · vol. 92 , pp. 102433 · doi:10.1016/j.bpobgyn.2023.102433 · PMID:38065008 · W4389001091
meta-analysis OA: closed CC0 ⤵ 9 in-corpus citations
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This systematic review and meta-analysis synthesized existing studies to evaluate the impact of high-intensity focused ultrasound (HIFU) treatment on reproductive outcomes in women with adenomyosis.

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Abstract

High-intensity focused ultrasound (HIFU) has emerged as a promising uterus-sparing and possibly fertility-sparing treatment modality for women with adenomyosis, especially those who desire to conceive. We conducted this systematic review and performed a meta-analysis on clinical studies aimed to improve reproduction in women with adenomyosis. After extensive search of PubMed and CNKI, we identified 10 studies published in English and Chinese involving a total of 557 patients with adenomyosis who desired to conceive after HIFU treatment. We found a pooled estimate of pregnancy rate of 53.4% and of the live birth rate of 35.2%, and there was a substantial heterogeneity among these studies. While there is a potential for HIFU treatment to improve fertility for patients with adenomyosis who desired to conceive, such evidence is very weak as of now. Comparative studies with much higher methodological rigor, preferably randomized clinical trials, are badly needed to further illuminate this issue.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (72)

Cited by (12)

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