Genetic variations in vascular endothelial growth factor but not in angiotensin I-converting enzyme genes are associated with endometriosis in Estonian women

Merit Lamp, Lamp M, Merli Saare, Triin Laisk, Karro H, Helle Karro, Ulle Kadastik, Ülle Kadastik, Kadastik U, Andres Metspalu, Metspalu A, Maire Peters, Andres Salumets
European journal of obstetrics, gynecology, and reproductive biology · 2010 · vol. 153(1) , pp. 85–89 · doi:10.1016/j.ejogrb.2010.07.021 · PMID:20685027 · W2107263503
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This study investigated genetic variations in vascular endothelial growth factor and angiotensin I-converting enzyme genes, finding an association only with vascular endothelial growth factor in Estonian women with endometriosis.

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Abstract

OBJECTIVE: To determine plausible associations between endometriosis and vascular endothelial growth factor gene (VEGF -2578 A/C, -1154 G/A, -634 G/C and 936 C/T), also angiotensin I-converting enzyme gene (ACE -240 A/T and 2350 A/G) single nucleotide polymorphisms (SNPs), as well as their respective haplotypes. STUDY DESIGN: PCR-based restriction fragment length polymorphism analysis was used to detect SNPs in VEGF and ACE genes in 150 Estonian women with endometriosis and 199 control subjects. RESULTS: The CC genotype of the VEGF -2578 A/C SNP was correlated with a decreased risk of endometriosis (OR=0.40, 95% CI 0.20-0.78). Other VEGF and ACE SNPs and haplotypes were not associated with endometriosis. CONCLUSION: This case-control study demonstrated that the VEGF -2578 A/C SNP may influence susceptibility to endometriosis in the Estonian population, while associations between endometriosis and other VEGF and ACE SNPs, as well as the respective haplotypes are unlikely.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Peptidyl-Dipeptidase A Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Vascular Endothelial Growth Factor A Adolescent Adolescent Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Estonia Estonia Female Female Genotype Genotype Haplotypes

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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