Shared genetics underlying epidemiological association between endometriosis and ovarian cancer

Lu Y, Yi Lu, Gabriel Cuellar-Partida, Gabriel Cuéllar-Partida, Painter JN, Jodie N. Painter, Dale R. Nyholt, Nyholt DR, Australian Ovarian Cancer Study, International Endogene Consortium (IEC), Morris AP, Andrew P. Morris, Peter A. Fasching, Fasching PA, Alexander Hein, Stefanie Burghaus, Beckmann MW, Matthias W. Beckmann, Diether Lambrechts, Van Nieuwenhuysen E, Els Van Nieuwenhuysen, Vergote I, Ignace Vergote, Adriaan Vanderstichele, Jennifer A. Doherty, Jennifer Anne Doherty, Doherty JA, Rossing MA, Mary Anne Rossing, Jenny Chang‐Claude, Wicklund KG, Kristine G. Wicklund, Jenny Chang-Claude, Chang-Claude J, Eilber U, Ursula Eilber, Rudolph A, Anja Rudolph, Shan Wang‐Gohrke, Shan Wang-Gohrke, Wang-Gohrke S, Marc T. Goodman, Natalia Bogdanova, Thilo Dörk, Dürst M, Matthias Dürst, Peter Hillemanns, Runnebaum IB, Ingo B. Runnebaum, Antonenkova N, Ralf Bützow, Natalia Antonenkova, Ralf Butzow, Butzow R, Leminen A, Arto Leminen, Heli Nevanlinna, Nevanlinna H, Liisa M. Pelttari, Edwards RP, Robert P. Edwards, Joseph L. Kelley, Kelley JL, Francesmary Modugno, Modugno F, Moysich KB, Kirsten B. Moysich, Ness RB, Roberta B. Ness, Rikki Cannioto, Cannioto R, Estrid Høgdall, Allan Jensen, Graham G. Giles, Fiona Bruinsma, Susanne K. Kjær, Susanne K Kjaer, Michelle A T Hildebrandt, Hildebrandt MA, Dong Liang, Lu KH, Karen H. Lu, Wu X, Xifeng Wu, Bisogna M, Maria Bisogna, Dao F, Fanny Dao, Douglas A. Levine, Cramer DW, Daniel W. Cramer, Kathryn L. Terry, Shelley S. Tworoger, Stacey A. Missmer, Line Bjørge, Missmer S, Stacey Missmer, Bjorge L, Line Bjorge, Reidun Kristin Kopperud, Salvesen HB, Helga B. Salvesen, Reidun K Kopperud, Kopperud RK, Bischof K, Katharina Bischof, Katja K H Aben, Lambertus A. Kiemeney, Leon F A G Massuger, Massuger LF, Angela Brooks‐Wilson, Brooks-Wilson A, Angela Brooks-Wilson, Sara H. Olson, Valerie McGuire, McGuire V, Rothstein JH, Joseph H. Rothstein, Weiva Sieh, Whittemore AS, Alice S. Whittemore, Cook LS, Nhu D. Le, Linda S. Cook, Le ND, C. Blake Gilks, Gilks CB, Jacek Gronwald, Gronwald J, Anna Jakubowska, Jan Lubiński, Jan Gawełko, Honglin Song, Song H, Jonathan P. Tyrer, Tyrer JP, Wentzensen N, Louise A. Brinton, Nicolas Wentzensen, Brinton L, Louise Brinton, Britton Trabert, Esther M. John, Jolanta Lissowska, John R. Mclaughlin, McLaughlin JR, Narod SA, Steven A. Narod, Hoda Anton‐Culver, Catherine Phelan, Phelan C, Hoda Anton-Culver, Anton-Culver H, Argyrios Ziogas, Ziogas A, Diana Eccles, Aleksandra Gentry‐Maharaj, Gayther SA, Simon A. Gayther, Gentry-Maharaj A, Aleksandra Gentry-Maharaj, Usha Menon, Susan J. Ramus, Wu AH, Anna H. Wu, Agnieszka Dansonka-Mieszkowska, Agnieszka Dansonka‐Mieszkowska, Jolanta Kupryjańczyk, Jolanta Kupryjanczyk, Timorek A, Agnieszka Timorek, Lukasz Szafron, Lukasz M. Szafron, Cunningham JM, Julie M. Cunningham, Fridley BL, Brooke L. Fridley, Stacey J. Winham, Bandera EV, Elisa V. Bandera, Elizabeth M. Poole, Poole EM, Terry K. Morgan, Morgan TK, Risch HA, Harvey A. Risch, Ellen L. Goode, Goode EL, Joellen M. Schildkraut, Schildkraut JM, Penelope M. Webb, Celeste Leigh Pearce, Celeste L Pearce, Pearce CL, Paul D P Pharoah, Berchuck A, Andrew Berchuck, Grant W. Montgomery, Pharoah PD, Montgomery GW, Krina T. Zondervan, Zondervan Kt, Georgia Chenevix-Trench, Georgia Chenevix‐Trench, MacGregor S, Stuart MacGregor
Human molecular genetics · 2015 · vol. 24(20) , pp. 5955–5964 · doi:10.1093/hmg/ddv306 · PMID:26231222 · PMC4581608 · W1885849841
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This study found shared genetic risks between endometriosis and most ovarian cancer histotypes, except mucinous, with clear cell carcinoma showing the strongest genetic correlation.

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Abstract

Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associations might be due to shared genetic aetiology. To address this, we used two endometriosis datasets genotyped on common arrays with full-genome coverage (3194 cases and 7060 controls) and a large ovarian cancer dataset genotyped on the customized Illumina Infinium iSelect (iCOGS) arrays (10 065 cases and 21 663 controls). Previous work has suggested that a large number of genetic variants contribute to endometriosis and ovarian cancer (all histotypes combined) susceptibility. Here, using the iCOGS data, we confirmed polygenic architecture for most histotypes of ovarian cancer. This led us to evaluate if the polygenic effects are shared across diseases. We found evidence for shared genetic risks between endometriosis and all histotypes of ovarian cancer, except for the intestinal mucinous type. Clear cell carcinoma showed the strongest genetic correlation with endometriosis (0.51, 95% CI = 0.18-0.84). Endometrioid and low-grade serous carcinomas had similar correlation coefficients (0.48, 95% CI = 0.07-0.89 and 0.40, 95% CI = 0.05-0.75, respectively). High-grade serous carcinoma, which often arises from the fallopian tubes, showed a weaker genetic correlation with endometriosis (0.25, 95% CI = 0.11-0.39), despite the absence of a known epidemiological association. These results suggest that the epidemiological association between endometriosis and ovarian adenocarcinoma may be attributable to shared genetic susceptibility loci.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Neoplasms Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Endometriosis Endometriosis Endometriosis Female Female Genetic Association Studies Genetic Association Studies Genetic Predisposition to Disease Genetic Predisposition to Disease Humans Humans Oligonucleotide Array Sequence Analysis Oligonucleotide Array Sequence Analysis Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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