PURPOSE: An understanding of the etiologic heterogeneity of ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, and lifestyle factors by histologic subty…
Disruption in circadian gene expression, whether due to genetic variation or environmental factors (e.g., light at night, shiftwork), is associated with increased incidence of breast, prostate, gastrointestinal and hematologic cancers and g…
ObjectiveTo examine the relationship of ovulation-stimulating drugs to risk of cancers other than breast and gynecologic malignancies.DesignRetrospective cohort study, with additional follow-up since initial report.SettingReproductive endoc…
ObjectiveTo evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer.DesignPooled genetic analysis.SettingUniversity hospital.Patient(s)Genetic data from 46,176 participants (15,361 ovarian cancer cases and…
Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associatio…
BackgroundAlthough fertility drugs stimulate ovulation and raise estradiol levels, their effect on breast cancer risk remains unresolved.MethodsAn extended follow-up was conducted among a cohort of 12,193 women evaluated for infertility bet…
OBJECTIVE: Pro-inflammatory mechanisms may explain the increased ovarian cancer risk linked to more lifetime ovulations, endometriosis, and exposure to talc and asbestos, as well as decreased risk with non-steroidal anti-inflammatory drugs.…
Although several risk factors are common to endometriosis and breast cancer, the results of observational studies of an association have so far been inconsistent. We evaluated the relationship between endometriosis and breast cancer on the …
Although several risk factors are common to endometriosis and breast cancer, the results of observational studies of an association have so far been inconsistent. We evaluated the relationship between endometriosis and breast cancer on the …
BACKGROUND: Although studies have found elevated risks of certain cancers linked to infertility, the underlying reasons remain unclear. METHODS: In a retrospective cohort study of 12,193 U.S. women evaluated for infertility between 1965 and…
OBJECTIVE: Although endometriosis and uterine leiomyomas are common conditions, the extent to which either is associated with certain types of malignancies remains uncertain. METHODS: Using record linkage techniques, we assessed the relatio…
ObjectiveTo evaluate the risk of ovarian cancer as related to underlying causes of infertility.DesignRetrospective observational cohort study.SettingFive large reproductive endocrinology practices.Patient(s)A total of 12,193 women evaluated…
ObjectivesOur goal was to determine the risk of cancer after hospitalization for endometriosis.Study designRecords of 20,686 women hospitalized with endometriosis during the period 1969 to 1983, as identified through the nationwide Swedish …