Origin of Peritoneal Cancer With Features of High-grade Serous Carcinoma: A Detailed Molecular Analysis

T Yamagata, Koichi Watanabe, Watanabe K, Koji Yamanoi, Nobuyuki Kakiuchi, Kakiuchi N, Ogura J, Jumpei Ogura, Taki M, Mana Taki, Ryusuke Murakami, Murakami R, Ken Yamaguchi, Hamanishi J, Junzo Hamanishi, Sachiko Minamiguchi, Minamiguchi S, Ogawa S, Seishi Ogawa, Masaki Mandai, Mandai M
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2024 · vol. 44(3) , pp. 280–285 · doi:10.1097/pgp.0000000000001069 · PMID:39254218 · W4402411952
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Whole-exome sequencing of a peritoneal cancer case revealed shared mutations with coexisting endometriosis, indicating a common clonal origin and suggesting endometriosis as a potential precursor for some peritoneal cancers.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-21 · read from full text ⓘ

This study investigated the molecular relationship between primary peritoneal cancer and coexisting endometriosis in a patient with a history of hysterectomy. Researchers performed whole-exome sequencing on multiple sites from both the tumor and endometriotic lesions to determine their clonal origins. The analysis revealed that the cancer cells shared specific mutations with one particular endometriosis tissue, indicating they originated from the same clone. These findings suggest that certain peritoneal cancers may develop directly from endometriotic implants rather than arising independently. Relevance to endometriosis: This paper is centrally about endometriosis, specifically examining its potential role as a precursor lesion for high-grade serous carcinoma of the peritoneum.

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Abstract

Primary peritoneal cancer has characteristics similar to high-grade serous carcinomas of ovarian and fallopian tube origin. However, the relationship between endometriosis and primary peritoneal cancer is not well understood. This study focuses on a case of peritoneal cancer in a patient who had undergone hysterectomy and bilateral salpingo-oophorectomy 5 yr before. In addition to morphology, there was a positive for TP53 in immunohistochemistry and homologous recombination deficiency test, which were similar to high-grade serous carcinomas. However, WT1 was negative in the tumor, and extensive endometriosis coexisted. To reveal the clonal relationship between tumor and endometriosis, we dissected 3 sites each from the tumor and endometriosis and performed whole-exome sequencing analysis. As a result, we found that the tumors were of identical origin. Contrarily, no shared mutations were found in the 3 endometriosis sites. Furthermore, several shared mutations were found between the tumor and 1 endometriosis tissue, showing that the tumor and 1 ectopic endometrial gland originated from the same clone. This study indicates that several peritoneal cancers may be derived from endometriosis. We should consider the possibility of more diverse origins of peritoneal cancer than we speculated before.
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Primary peritoneal cancer has characteristics similar to high-grade serous carcinomas of ovarian and fallopian tube origin. However, the relationship between endometriosis and primary peritoneal cancer is not well understood. This study focuses on a case of peritoneal cancer in a patient who had undergone hysterectomy and bilateral salpingo-oophorectomy 5 yr before. In addition to morphology, there was a positive for TP53 in immunohistochemistry and homologous recombination deficiency test, which were similar to high-grade serous carcinomas. However, WT1 was negative in the tumor, and extensive endometriosis coexisted. To reveal the clonal relationship between tumor and endometriosis, we dissected 3 sites each from the tumor and endometriosis and performed whole-exome sequencing analysis. As a result, we found that the tumors were of identical origin. Contrarily, no shared mutations were found in the 3 endometriosis sites. Furthermore, several shared mutations were found between the tumor and 1 endometriosis tissue, showing that the tumor and 1 ectopic endometrial gland originated from the same clone. This study indicates that several peritoneal cancers may be derived from endometriosis. We should consider the possibility of more diverse origins of peritoneal cancer than we speculated before. Origin of Peritoneal Cancer With Features of High-grade Serous Carcinoma: A Detailed Molecular Analysis - Buy - SDC

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Condition tags

endometriosis

MeSH descriptors

Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous Cystadenocarcinoma, Serous

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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