Karen H. Lu

Mesonephric-like adenocarcinoma (MLA) is a rare and aggressive gynecologic malignancy that has only been recognized in the last decade. It arises in the endometrium, ovaries, and other extrauterine sites (often in association with endometri…

Abstract Advanced stage high grade serous ovarian cancer (HGSC) metastasizes preferentially to the omentum, which is a well-vascularized fold of peritoneal tissue covered by mesothelial cells and a major site of intra-abdominal fat accumula…

PURPOSE: We aimed to describe RAS mutations in gynecologic cancers as they relate to clinicopathologic and genomic features, survival, and therapeutic implications. EXPERIMENTAL DESIGN: Gynecologic cancers with available somatic molecular …

PDF file - 387K, Three-lineage differentiation of O-ASC.

PDF file - 387K, Three-lineage differentiation of O-ASC.

PDF file - 678K, O-ASC do not co-localize with CD31 positive endothelial cells.

PDF file - 678K, O-ASC do not co-localize with CD31 positive endothelial cells.

PDF file - 202K, Quantification of histological and immunofluorescence tissue analysis.

PDF file - 202K, Quantification of histological and immunofluorescence tissue analysis.

PDF file - 139K, Endometrial Hec1a cancer cell proliferation in co-culture with OSC, MSC, ASC and WI38 fibroblasts.

PDF file - 139K, Endometrial Hec1a cancer cell proliferation in co-culture with OSC, MSC, ASC and WI38 fibroblasts.

PDF file - 99K, Migration of stromal cells in response to Hec1a conditioned media.

PDF file - 99K, Migration of stromal cells in response to Hec1a conditioned media.

PDF file - 281K, Hec1a secrete IL8 and CXCL1.

PDF file - 281K, Hec1a secrete IL8 and CXCL1.

PDF file - 1.0MB, Expression of IL8 / CXCL1 receptors in mesenchymal cells.

PDF file - 1.0MB, Expression of IL8 / CXCL1 receptors in mesenchymal cells.

Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard…

PURPOSE OF REVIEW: Both conventional and novel approaches to early detection of ovarian cancer are reviewed in the context of new developments in our understanding of ovarian cancer biology. RECENT FINDINGS: While CA125 as a single value l…

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptib…

OBJECTIVE: To estimate the percentage of women with a hematologic cancer who present with abnormal uterine bleeding (AUB). METHODS: We performed a retrospective analysis of the records of women with hematologic malignancies treated at our …

BACKGROUND: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating c…

OBJECTIVE: Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as wit…

PURPOSE: The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endometrial cancer (EC). Hormonal manipulation leads to response in some patients with EC, but resistance derived from PI3K pathway activation has been docum…

Bilateral salpingo-oophorectomy (BSO) has become the standard-of-care for risk reduction in women at hereditary risk of ovarian cancer. Although this procedure significantly decreases both the incidence of and mortality from ovarian cancer,…