Neal Mahutte

Endometriosis is found in up to 60% of women with dysmenorrhea, 40-50% of reproductive age women with pelvic pain or deep dyspareunia, and 30-40% of women with infertility.1 Endometriosis is defined as the presence and proliferation of endo…

With the introduction of recombinant human growth hormone (GH), GH-deficient (GHD) children have been treated with larger doses and in a continuous fashion and have been followed to final height. Near-adult height data were reported by Blethe…

Endometriosis is associated with changes in both cell-mediated and humoral immunity. Although the peritoneal fluid of women with endometriosis contains increased numbers of immune cells, their function appears to be altered from an inhibito…

Debate continues about the effect of ovarian endometriomas on techniques of assisted reproduction. Possibly, an ovarian endometriotic cyst could impair oocyte quality and limit the response to ovarian hyperstimulation. Alternately, previous…

PROBLEM: Pregnancy-associated plasma protein-A (PAPP-A) belongs to a group of glycoproteins isolated from extracts of human placenta. Healthy ovarian and uterine tissues are also known to express PAPP-A. We hypothesized that PAPP-A levels m…

BACKGROUND: The role of leptin in reproductive processes has received increasing attention. Because leptin has intrinsic angiogenic properties, may be induced by inflammatory cytokines and induces matrix metalloproteinases, we examined peri…

PROBLEM: Chemokines are increasingly recognized as important regulators of uterine function. METHODS OF STUDY: The following is a review of uterine chemokines, especially monocyte chemotactic protein (MCP)-1, interleukin (IL)-8, and regulat…

The preponderance of recent data suggests that endometriosis does not adversely affect in-vitro fertilization pregnancy rates. However, many studies demonstrate impaired oocyte quality, decreased fertilization, and compromised implantation …