Takao Fukaya

No ORCID on file · 22 papers in corpus · active 1993-2019

Study types

  • article 19
  • other 2
  • review 1

Condition tags

  • endometriosis 22
  • dysmenorrhea 2
  • infertility 2
  • chronic_pelvic_pain 1
  • endometrioma 1
article 2019
Human Reproduction ·doi:10.1093/humrep/dez028

STUDY QUESTION: Does the GnRH antagonist, ASP1707, reduce endometriosis-associated pelvic pain? SUMMARY ANSWER: ASP1707 significantly reduced endometriosis-associated pelvic pain in a dose-related manner. WHAT IS KNOWN ALREADY: GnRH agonist…

article 2015

Increased killer inhibitory receptor 2DL1 expression among natural killer cells in women with pelvic endometriosis

article 2013
·doi:10.5180/jsgoe.29.318

Objective: To evaluate the management of young women with endometriosis after conservative laparoscopic surgery.Design: Retrospective study.Setting: Department of Obstetrics and Gynecology, Kochi Medical School.Patients: Sixty-four women ag…

review 2012
Frontiers in bioscience (Scholar edition) ·doi:10.2741/s353

Impaired natural killer (NK) activity in women with endometriosis is thought to promote implantation and progression of endometrial tissue, in accord with Sampson's hypothesis. However, the mechanisms responsible for decreased NK cell activ…

article 2010
·doi:10.5180/jsgoe.26.511

Objective: To evaluate the efficacy of laparoscopic surgery for endometriosis-associated infertility.Design: Retrospective study.Setting: Department of Obstetrics and Gynecology, Kochi Medical School.Patient(s): Sixty-five women with endome…

other 2009
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.12.005

OBJECTIVE: To investigate menstrual cycle changes in expression by eutopic endometrium of a nonclassic human leukocyte antigen, HLA-G, which binds to the killer immunoglobulin-like receptor (KIR) 2DL4 (CD158d) on natural killer (NK) cells. …

article 2007
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.02.027

ObjectiveTo investigate the macrophage response in endometriosis by determining the expression and localization of human leukocyte antigen (HLA)-ABC and HLA-DR by the peritoneal fluid (PF) macrophages and PF concentrations of interferon (IF…

article 2006
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/j.1600-0897.2005.00332.x

PROBLEM: We investigated host immunologic responses to endometriosis by comparing immune cell surface antigens in peripheral blood (PB) and peritoneal fluid (PF) from women with endometriosis with those in PB and PF from other patients. MET…

other 2005
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/j.1600-0897.2005.00271.x

PROBLEM: We investigated inhibitory and activation motif expression of killer immunoglobulin-like receptor (KIR) by natural killer (NK) cells, which may be pathogenetically involved in endometriosis. METHOD OF STUDY: We compared cells from…

article 2005
Fertility and Sterility ·doi:10.1016/j.fertnstert.2004.11.039

ObjectiveTo investigate the macrophage response in endometriosis, we determined expression of human leukocyte antigen (HLA)-ABC, HLA-DR, and their costimulatory molecules by peritoneal fluid (PF) macrophages.DesignCase-control study of immu…

article 2004
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/j.1600-0897.2004.00170.x

PROBLEM: Natural killer (NK) dysfunction is considered to contribute to the pathogenesis of endometriosis. In this study, we investigated the host immune response to endometriosis in terms of killer inhibitory receptor (KIR) expression by N…

article 2003
Fertility and Sterility ·doi:10.1016/s0015-0282(03)00780-5

ObjectiveTo investigate the macrophage response in endometriosis, we determined the expression of human leukocyte antigen (HLA)-DR, intercellular adhesion molecule (ICAM)-1, and CD14 on peritoneal macrophages.DesignCase-control study of imm…

article 2002
Fertility and Sterility ·doi:10.1016/s0015-0282(01)03249-6

ObjectiveTo investigate host immunologic response to endometriosis in terms of intercellular adhesion molecule (ICAM)-1 expression by macrophages and killer cell inhibitory receptor (KIR) expression by natural killer (NK) cells.DesignCase-c…

article 2002
Fertility and Sterility ·doi:10.1016/s0015-0282(01)02964-8

ObjectiveTo investigate the host immunologic response to endometriosis in terms of killer inhibitory receptor (KIR) expression by natural killer (NK) cells.DesignCase-control study of immunologic markers.SettingUniversity hospital.Patient(s…

article 2000
Fertility and Sterility ·doi:10.1016/s0015-0282(00)00527-6

ObjectiveTo evaluate the expression of estrogen receptor (ER)-alpha and ER-beta messenger RNA (mRNA) in ovarian endometriosis.DesignProspective study.SettingUniversity hospital.Patient(s)Patients with endometriosis and patients with uterine…

article 1998
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/j.1600-0897.1998.tb00420.x

PROBLEM: Factors regulating fibrosis in peritoneal endometriosis are poorly understood. We hypothesized that mast cell proteases may play a role in the process of fibrosis in peritoneal endometriosis. As the first step in examining the poss…

article 1997
Fertility and Sterility ·doi:10.1016/s0015-0282(97)00226-4

ObjectiveWe evaluated the secretion of hepatocyte growth factor by eutopic endometrial stromal cells in vitro.DesignEutopic endometrial stromal cells were isolated and the culture supernatants were collected after 48 hours of incubation. Th…

article 1996
The Tohoku journal of experimental medicine ·doi:10.1620/tjem.178.339

The clinical and pathological features of an apparently unique case of an endometrial cyst of the uterus are reported. The cyst was located within the myometrium of a 16-year-old woman suffering from dysmenorrhea. After excision of the cyst…

article 1995
·doi:10.2530/jslsm1980.16.supplement_67

Among the women who suffered from endomertiosis, pelvic adhesion and polycystic ovarian deseas were treated by endosopic approach to evaluate the effectiveness and consequent pregnancy rate after endoscopic treatment. For endoscopic incisio…

article 1994
The Tohoku journal of experimental medicine ·doi:10.1620/tjem.172.221

FUKAYA, T., SUGAWARA, J., YOSHIDA, H. and YAJIMA, A. The Role of Macrophage Colony Stimulating Factor in the Peritoneal Fluid in Infertile Patients with Endometriosis. Tohoku J. Exp. Med., 1994, 172 (3), 221-226-Macrophage colony stimulatin…

article 1993
American Journal of Obstetrics and Gynecology ·doi:10.1016/0002-9378(93)90650-8

ObjectiveTo establish a relationship between pelvic pain and the stage and severity of pelvic endometriosis determined according to the revised American Fertility Society classification.Study designRetrospective study of 618 cases diagnosed…

article 1993
American Journal of Obstetrics and Gynecology ·doi:10.1016/0002-9378(93)90649-4

ObjectiveTo clarify the pathogenesis of endometriosis on the basis of analysis of primary lesion sites, age at onset, rate of progression, and response to drug treatment.Study designThe clinical records of 690 women with laparoscopically co…