Laparoscopic evaluation of the onset and progression of endometriosis

H Hoshiai, Hiroshi Hoshiai, Hoshiai H, M Ishikawa, Ishikawa M, Motoharu Ishikawa, Y Sawatari, Sawatari Y, Yoshiharu Sawatari, Noda K, K. Noda, Kichiro Noda, Fukaya T, Takao Fukaya, T. Fukaya
American journal of obstetrics and gynecology · 1993 · vol. 169(3) , pp. 714–719 · doi:10.1016/0002-9378(93)90649-4 · PMID:8372885 · W2041495081
article OA: closed CC0 ⤵ 36 in-corpus citations
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This study used laparoscopy to observe the initial development and advancement of endometriosis in subjects.

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Abstract

ObjectiveTo clarify the pathogenesis of endometriosis on the basis of analysis of primary lesion sites, age at onset, rate of progression, and response to drug treatment.Study designThe clinical records of 690 women with laparoscopically confirmed endometriosis were retrospectively analyzed based on the revised American Fertility Society point system.ResultsThe primary site of endometriosis was the uterosacral ligament and pelvic peritoneum/pouch of Douglas in 73% of patients with stage I disease, whereas only 16% had ovarian lesions. However, disease progression was associated with an increasing frequency of ovarian lesions. In terms of the revised American Fertility Society score, endometriosis progressed at a mean rate of 0.3 point per month. Thus the earliest onset of endometriosis was estimated at 3 to 4 years after menarche. Drug therapy improved the revised American Fertility Society score by about 50%. Patients with a low response to an initial cycle of therapy generally showed further improvement after an additional treatment cycle.ConclusionsBecause endometriosis may occur as early as 3 to 4 years after menarche and gradually progresses, drug therapy, including long-term treatment, should be carried out in women with definitive evidence of endometriosis who must maintain their reproductive potential.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Adolescent Adult Buserelin Buserelin Colorectal Neoplasms Colorectal Neoplasms Colorectal Neoplasms Colorectal Neoplasms Danazol Danazol Endometriosis Endometriosis Endometriosis Fallopian Tube Neoplasms Fallopian Tube Neoplasms Fallopian Tube Neoplasms Fallopian Tube Neoplasms Female Fertility

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (34)

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License: CC0 · commercial use OK