Yutaka Osuga
No ORCID on file
· 270 papers in corpus
· active 1995-2026
Study types
- article 198
- other 29
- review 13
- preprint 10
- book-chapter 7
Condition tags
- endometriosis 201
- adenomyosis 54
- endometrioma 38
- dysmenorrhea 28
- infertility 24
- chronic_pelvic_pain 11
- dyspareunia 5
- bowel_endometriosis 4
- bladder_endometriosis 3
- mesh:D004716 3
Top journals
Frequent coauthors
- Kaori Azuma Koga 153
- Yasushi Hirota 132
- Tomoyuki Hirata 112
- Miyuki Harada 109
- Tomoyuki Fujii 75
- Yojiro Taketani 75
- Osamu Yoshino 71
- Osamu Wada-Hiraike 54
- Tomone Yano 53
- Masashi Takamura 49
other
2022
Long-term conservative management of symptomatic bladder endometriosis: A case series of 17 patients
OBJECTIVES: This study aimed to evaluate the course of long-term conservative management of bladder endometriosis (BE). MATERIALS AND METHODS: We retrospectively reviewed 17 cases of BE conservatively managed without surgery in our facilit…
case-report
2022
Imaging and histological changes occurring in adenomyosis due to pregnancy are unclear. A 38-year-old nulliparous woman presented with dysmenorrhea and infertility. Pelvic magnetic resonance imaging (MRI) showed diffuse-type adenomyosis. Fo…
article
2022
Dienogest (DNG) is widely used to treat dysmenorrhea associated with estrogen-dependent diseases such as endometriosis and adenomyosis. DNG becomes unnecessary after menopause when estrogen secretion declines drastically. However, there are…
article
2022
Uterine fibroids are known to degenerate during pregnancy, but it is unknown if similar pathologic condition occurs in adenomyosis. A 38-year-old para 1 woman exhibited uterine tenderness and a markedly elevated inflammatory response at 22 …
article
2022
Abstract Background In women with endometriosis, the association between ovarian function, hormones, and bone mineral density (BMD) is unclear. Therefore, this study aimed to elucidate the association between changes in bone mineral density…
rct
2022
OBJECTIVE: To evaluate the efficacy and safety of 40-mg relugolix (REL) compared with those of leuprorelin (LEU) in women with endometriosis-associated pain. DESIGN: Phase 3, multicenter, randomized, double-blind, double-dummy, active-cont…
article
2022
Endometriosis, which exhibits enigmatic pathological features such as stromal fibrosis and proliferation of ectopic epithelial cells, is known as a refractory disease. Mesenchymal stem cells modulate the fibrosis in stromal tissues through …
article
2021
article
2021
In endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of M2 MΦ is unclear. CD206 positive (+) MΦ is classified in one of M2 type MΦs and are known to produce cytokines and chemokines. In the present study, we u…
other
2021
AIM: We aimed to describe the clinical presentation, operative or medical management, and postoperative recurrence of bladder endometriosis (BE). METHODS: We conducted a national survey to investigate BE cases from 2006 to 2016 in Japan. H…
other
2021
AIM: The purpose of this study was to evaluate the current state and clinical characteristics of spontaneous hemoperitoneum in pregnancy (SHiP) in Japan by performing a comprehensive survey. METHODS: We reviewed data on pregnant women who …
book-chapter
2021
article
2021
Objective: Long-term administration of dienogest, which is known to have effect on bone mineral density, is frequently done in patients with endometriosis and adenomyosis, but a few studies focused on the bone mineral density changes after …
preprint
2021
Abstract Background In women with endometriosis, the association between ovarian function, hormones, and bone mineral density (BMD) is unclear. Therefore, this study aimed to elucidate the correlation between changes in bone mineral density…
article
2021
rct
2021
BACKGROUND: Relugolix is a once-daily, oral, nonpeptide, gonadotropin-releasing hormone receptor antagonist. The aim of this study was to evaluate safety of relugolix over 24 weeks in women with endometriosis-associated pain. METHODS: This…
article
2021
Sphingosine 1-phosphate (S1P), an inflammatory mediator, is abundantly contained in red blood cells and platelets. We hypothesized that the S1P concentration in the peritoneal cavity would increase especially during the menstrual phase due …
article
2021
子宮内膜症患者では、腹腔内の免疫環境の異常が指摘されている。Macrophage(MΦ)は、腹腔内の主な免疫細胞で、炎症性疾患である子宮内膜症患者の腹腔内においては、抗炎症・免疫抑制性のM2 MΦが優位と報告されているが、なぜM2 MΦ優位なのか、M2 MΦが子宮内膜症の増悪あるいは抑制因子であるのか、その意義は明らかにされていない。我々は逆流月経血中のalarmin IL-33に着目し、IL-33が腹腔内免疫環境をM2 MΦ優位に誘導する因子の1つであることをin vitr…
other
2021
OBJECTIVES: This study aimed to determine the systemic and local proportions, focal localization, and characteristics of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in endometriosis. STUDY DESIGN: Peripheral blood and pe…
article
2021
preprint
2021
Abstract Endometriosis, which exhibits enigmatic pathological features such as stromal fibrosis and proliferation of ectopic epithelial cells, is known as a refractory disease. Mesenchymal stem cells modulate the fibrosis in stromal tissues…
article
2021
Ulipristal acetate (UPA), a selective progesterone receptor modulator, is used for the treatment of uterine fibroids and selectively inhibits the proliferation and inflammation of leiomyoma cells. As few studies have focused on the molecula…
article
2021
article
2020
We present a case of hemorrhagic shock occurred during dienogest therapy for uterine adenomyosis which necessitated an emergency hysterectomy. The patient was a 45-year-old woman with adenomyosis. Magnetic resonance imaging showed type I ad…
article
2020
The uterus plays an important and unique role during pregnancy and is a dynamic organ subjected to mechanical stimuli. It has been reported that infertility occurs when the peristalsis is prevented, although its mechanisms remain unknown. I…