Nationwide survey (Japan) on spontaneous hemoperitoneum in pregnancy
Miki Hagimoto,
Hagimoto M,
Hiroaki Tanaka,
Tanaka H,
Yutaka Osuga,
Osuga Y,
Miura K,
Kiyonori Miura,
Saito S,
Shigeru Saito,
Sato S,
Shoji Sato,
Sugawara J,
Junichi Sugawara,
Tomoaki Ikeda,
Ikeda T
other
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public-domain-us
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by qwen3.7-flash, 2026-08-20
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A nationwide survey of 31 Japanese cases found spontaneous hemoperitoneum in pregnancy is linked to endometriosis and causes maternal death or poor fetal prognosis, with preterm birth being higher in the poor prognosis group.
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by qwen3.7-flash, 2026-09-05
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This nationwide Japanese survey analyzed 31 cases of spontaneous hemoperitoneum in pregnancy (SHiP) among 267 reported pregnancies over a five-year period. The study found that ovarian cysts were the most common cause, with ruptured corpus luteum cysts accounting for 42% of cases, while endometriosis-related lesions were identified in only 10%. Maternal mortality occurred in one case due to hypovolemic shock, and surgical intervention was required for 53% of patients, though most achieved successful delivery. Relevance to endometriosis: listed as one potential etiology for SHiP (10% of cases), though the paper's main focus is on obstetric emergencies rather than endometriosis management.
Abstract
AIM: The purpose of this study was to evaluate the current state and clinical characteristics of spontaneous hemoperitoneum in pregnancy (SHiP) in Japan by performing a comprehensive survey.
METHODS: We reviewed data on pregnant women who developed SHiP during 2013-2017 (for 5 years), and were admitted to any of the perinatal centers in Japan. The survey assessed maternal background and maternal and neonatal prognosis. We divided the cases into two groups, favorable and poor prognosis groups, and made comparisons between the two groups.
RESULTS: Of the 407 facilities in Japan, 267 (66%) facilities responded to our survey. Overall, 31 cases of SHiP were registered. Maternal death occurred in one case (3%) due to liver bleeding with an unknown cause. Of 23 cases with a SHiP onset during pregnancy, 12 (53%) had been misdiagnosed as placental abruption. The prognosis for the fetuses included miscarriage or stillbirth in three cases (10%) and asphyxia in 12 cases (42%). There was no significant correlation between the amount of intra-abdominal blood loss and neonatal prognosis based on umbilical artery pH. Incidences of preterm birth <32 gestational weeks (adjusted odds ratio, 35.75; 95% confidence interval, 3.46-368.82) were higher in the poor prognosis group than that in the favorable group. Endometriosis and artificial reproductive techniques were both associated with 19% of all cases of SHiP.
CONCLUSION: SHiP was associated with maternal death and poor fetal prognosis. Prematurity and persistent uterine contractions which might be misdiagnosed as placental abruption seem to contribute to poor fetal prognosis.
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Nationwide survey (Japan) on spontaneous hemoperitoneum in pregnancy
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Condition tags
endometriosis
MeSH descriptors
Hemoperitoneum
Hemoperitoneum
Hemoperitoneum
Hemoperitoneum
Premature Birth
Premature Birth
Female
Humans
Infant, Newborn
Japan
Japan
Placenta
Pregnancy
Pregnancy Outcome
Retrospective Studies
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- last seen: 2026-09-30T06:18:36.089610+00:00
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- last seen: 2026-05-13T22:24:37.768885+00:00
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