Raden Muharam

BACKGROUND: Genetic factors are contributing substantially to endometriosis risk, however, there is limited data on genetic variant associations specific to ovarian endometriosis, especially in Indonesian populations. Understanding the gene…

Menstrual blood flow is reversed through the fallopian tubes during the menstrual process and implants outside the uterus, which is the theory of pathogenesis in endometriosis sufferers. This study aims to analyze the level of DNA methylati…

Endometriosis is a chronic gynecological condition defined by the ectopic presence of endometrial-like tissue outside the uterine cavity, often resulting in debilitating symptoms and significant impacts on quality of life. While the exact e…

PURPOSE: This study aimed to measure the correlation between miR-183 and gene expression that regulates apoptosis and adhesion mechanism that may be linked to the pathogenesis of endometriosis. PATIENTS AND METHODS: Forty-four subjects, in…

Abstract Background Endometriosis, a prevalent gynecological disorder, poses significant challenges in diagnosis and treatment, often leading to delayed care and compromised quality of life. With the implementation of the Indonesian Nationa…

OBJECTIVES: Endometriosis is a common gynecological disease with a significant economic burden. Growing evidence has suggested the role of aberrant gene expression and epigenetic mechanisms in the pathogenesis of endometriosis. This study a…

Aims and background: Currently, there is no consensus on the standardization of clinical phenotype data for endometriosis patients.The WERF-Endometriosis Phenome and Biobanking Harmonization Project initiated the development of standardizat…

BACKGROUND: ) 3 expression in women with endometriosis. MATERIALS AND METHODS: . RESULTS: expression in eutopic endometrium obtained from women with endometriosis (r=-0.544, P=0.029). Expression of the miR-93 was also negatively correlated …

R Muharam,1 Titi Amalia,1 Gita Pratama,1 Achmad Kemal Harzif,1 Feranindhya Agiananda,2 Mila Maidarti,1 Mazaya Azyati,1 Kanadi Sumapraja,1 Hariyono Winarto,1 Budi Wiweko,1 Andon Hestiantoro,1 Eva Suarthana,3 Togas Tulandi3 1Department of Obs…

BACKGROUND: Endometriosis is a condition associated with pelvic pain, infertility, and possibly with decreased quality of life as well as psychiatric disorder. The purpose of our study was to evaluate the association between pain characteri…

Background: Endometriosis is believed to be associated with dysfunction of the lymphocyte population and cytotoxicity of natural killer (NK) cells, induced by the production of interleukin-2 (IL-2). Objective: This study aimed to investigat…

Objective: This study examined the correlation of the type of surgery and adherence to the clinical pathway corresponding to the national guidelines in terms of quality and cost control. Methods : Quantitative economic evaluation was condu…

Background: Natural killer (NK) cells play a role in pathogenesis of endometriosis. Lower expressions of NK cells receptor group 2D (NKG2D) ligands inhibits cytotoxic activity of NK cells; a common immunity avoidance mechanism in neoplasms.…

Background: Endometriosis is a health problem that causes various biological, psychological, and social problems. Patient-centered care is the best standard of care in endometriosis cases. ENDOCARE is an questionnaire assessing all dimensio…

Transient Receptor Ankyrin Member 1 (TRPA1) is an ion channel family protein that regulates pain sensation through sensory neurons' activity. This study's purpose to analyzes the DNA methylation and mRNA expression level of the TRPA1 gene i…

BACKGROUND: Endometriosis is closely associated with delayed diagnosis due to the lack of a definitive and sensitive noninvasive approach. The use of calprotectin in inflammatory process has been demonstrated in various inflammatory disease…

It has been postulated that the immune system is impaired in individuals with endometriosis, with attention directed to natural killer (NK) cells. Specifically, it has been hypothesized that altered numbers of peripheral NK cells in blood a…

OBJECTIVE: Endometriosis is a multifactorial disease that affects 10% of women of childbearing age. Its development is known to be related to the MMP-2 gene. Specifically, the expression of MMP-2 is increase in endometriosis. The aim of thi…

Abstract It has been known that the EGFR have the role for regulation the cytoskeleton activity and its expression increased in endometriosis tissue. The aim of this study was to evaluate the DNA methylation of the EGFR gene that might caus…

Background: Poor ovarian reserve and a high rate of pregnancy failure associated with low quality and quantity of oocytes are observed in poor responders to in vitro fertilization. Objective: To assess the effect of age, body mass index (BM…

Focal adhesion molecules involve in cellular migration, attachment, and play a role in endometriosis pathomechanisms. Recent studies showed that the expression of RAC1, a gene encoded focal adhesion molecule, was predominantly found in endo…

Abstract Endometriosis is characterized by the presence of endometrial-like tissues located outside the uterine cavity. The expression of focal adhesion genes including FN1 gene increased in endometriosis. Epigenetic factors play a role in …

Background: Endometriosis is one of the most common conditions causing infertility and an indication to undergo in vitro fertilization (IVF). High apoptosis rate and oxidative stress in patients with endometriosis are believed to negativel…

Endometriosis is a disease characterized by implantation of endometrial-like tissues outside the uterus. Until now, its pathogenesis of remains unclear. Previous studies have suggested a possible role of epigenetics in endometriosis. The pu…