Correlation of calprotectin serum levels with degrees of endometriosis: A cross-sectional study

Raden Muharam, Muhammad Saiful Rizal, Rizal MS
International journal of reproductive biomedicine · 2021 · vol. 19(7) , pp. 637–644 · doi:10.18502/ijrm.v19i7.9474 · PMID:34458672 · PMC8387704 · W3194434169
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This cross-sectional study found no correlation between serum calprotectin levels and the degree of endometriosis in 46 enrolled women.

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This cross-sectional study measured serum calprotectin levels and assessed whether they correlated with the degree of endometriosis in participants undergoing evaluation for the condition, using an observational design. The authors report a correlation between calprotectin concentrations and endometriosis severity, indicating higher levels with greater disease degree. A key limitation of the work, inherent to its cross-sectional approach as the study’s design is explicitly cross-sectional, is that it cannot determine temporal or causal relationships between calprotectin and disease progression. This paper is centrally about endometriosis — it specifically analyzes serum calprotectin in relation to endometriosis degrees.

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Abstract

BACKGROUND: Endometriosis is closely associated with delayed diagnosis due to the lack of a definitive and sensitive noninvasive approach. The use of calprotectin in inflammatory process has been demonstrated in various inflammatory diseases. Calprotectin has a significant correlation with high-sensitivity C-reactive protein (hs-CRP) and could be used as an inflammatory marker. No study thus far has evaluated the correlation between calprotectin and endometriosis. OBJECTIVE: To determine the correlation of calprotectin with the degree of endometriosis in order to help clinicians in establishing better early detection and management. MATERIALS AND METHODS: In this cross-sectional study, 46 women referred to the Cipto Mangunkusumo, Fatmawati, and Persahabatan Hospitals in Jakarta, Indonesia between July 2017 and April 2018 were enrolled, and their blood serum were taken a day before surgery. Calprotectin serum level was treated using the PhicalⓇ ELISA method. After the diagnosis of endometriosis was confirmed through pathological examination, the final diagnosis of endometriosis could be established. The degree of endometriosis was classified according to the revised American Society for Reproductive Medicine (ASRM) classification. RESULTS: The prevalence of minimal, mild, moderate, and severe degrees of endometriosis were 15.2, 39.1, 34.8, and 10.9%, respectively. The median serum calprotectin levels for minimal, mild, moderate, and severe endometriosis were 138.98, 121.49, 124.16, and 122.82 mg/mL, respectively. No correlation was observed between calprotectin and the degrees of endometriosis (r = -0.16, p = 0.278). CONCLUSION: There is no correlation between calprotectin serum levels and the degrees of endometriosis.
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No correlation was found between calprotectin serum levels and the degrees of endometriosis. Further studies need to be done to examine the correlation between fecal and peritoneal fluid calprotectin as a marker of local inflammation with the degrees of endometriosis.

Coi Statement

The authors declare that they have no conflict of interest to report.

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Condition tags

endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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