Jouko Halme

The natural history of endometriosis, including the belief that it is a progressive disease, is reviewed with the help of a large, cross-sectional, prospective study and a smaller longitudinal study. Two studies are reviewed that address th…

The natural history of endometriosis, including the belief that it is a progressive disease, is reviewed with the help of a large, cross-sectional, prospective study and a smaller longitudinal study. Two studies are reviewed that address th…

We examined the release in vitro of tumor necrosis factor-alpha (TNF-alpha) by peritoneal macrophages and peripheral blood monocytes following incubation with toxic shock syndrome toxin-1 (TSST-1). We obtained peritoneal macrophages from 22…

This paper has discussed the evidence for the presence of infertility in patients with endometriosis and more critically reviewed some of the studies that have addressed the impact of various potential local peritoneal mechanisms that may l…

Late proliferative phase endometrial stromal cells grown in short-term culture were used as a model for the stromal component of endometriotic implants. Cells were grown in medium alone and in medium supplemented by 5, 10, and 20% concentra…

Fibronectin, a known growth factor for fibroblasts, is produced by alveolar macrophages from patients with interstitial pulmonary fibrosis. Because peritoneal macrophages have been implicated in the disease process of endometriosis, we meas…

This study compared peritoneal fluid volume, macrophage count, and macrophage concentration by diagnosis and cycle week of 426 patients undergoing laparoscopy. Patient diagnosis and cycle week had no significant interaction. Peritoneal flui…

Forty-four patients with and without mild endometriosis were tested for the presence in peritoneal fluid of autoantibodies against endometrial and ovarian antigens. Five patients with endometriosis and one patient in the control group had s…

One case of extensive endometriosis with ascites in a young nulliparous woman is reported. The patient had been maintained on suppressive therapy with danazol for over two years, demonstrating the feasibility of conservative management in t…

Macrophages have been identified in the developing corpus luteum in several species, including man, and also constitute approximately 90% of cells in the peritoneal cavity. We studied the effect of peritoneal macrophages or blood monocytes …

Blood was found in the peritoneal fluid in 90% of women with patent tubes at laparoscopy during perimenstrual time. If the fallopian tubes were occluded, then only 15% of patients had evidence of blood in the pelvis. Also, 90% of patients w…

Human peritoneal macrophages obtained from females undergoing laparoscopic examination have been investigated. Morphologic heterogeneity as well as a wide variation in the content of nonspecific esterase, acid phosphatase (AP), and myeloper…

A recent report states that the number of macrophages in peritoneal fluid is higher in infertile women, with or without endometriosis, than it is in fertile women. Activated macrophages are postulated to affect fertility by phagocytosis or …