Potential use of ellagic acid for endometriosis treatment: its effect on a human endometrial cell cycle, adhesion and migration

B A Mc Cormack, Bárbara Andrea Mc Cormack, M A Bilotas, Mariela Bilotas, Daniela Madanes, D Madanes, A G Ricci, Analía Gabriela Ricci, J J Singla, José Javier Singla, R I Barañao, Rosa Inés Barañao
Food & function · 2020 · vol. 11(5) , pp. 4605–4614 · doi:10.1039/d0fo00267d · PMID:32400804 · W3019471373
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Ellagic acid treatment inhibited human endometrial cell adhesion, migration, and G2/M cell cycle progression in vitro, suggesting potential therapeutic benefits for endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

The paper evaluated whether ellagic acid (50 and 100 μM) affects endometrial stromal cell cycle progression, adhesion, and migration, using endometrial primary cultures from women with and without endometriosis and endometrial cell lines, after 24 or 48 hours of treatment. Ellagic acid arrested the endometrial stromal cell cycle at the G2/M phase after 48 hours, decreased migration in ECC-1 and T-HESC cells at specific time points, and reduced T-HESC and ECC-1 adhesion to plastic after 24 hours, while no effect on cell proliferation was detected. The study is limited to in vitro systems and does not establish in vivo efficacy. This paper is centrally about endometriosis — it tests ellagic acid’s effects on human endometrial cell cycle, adhesion, and migration as relevant mechanisms altered in endometriosis.

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Abstract

Endometriosis is a common and challenging condition of reproductive-aged women that is defined as the presence of endometrial-like tissue outside the uterine cavity. Despite its prevalence, there is still no effective therapeutics; so we aim to evaluate the ellagic acid (EA) effect on the most relevant aspects that are known to be altered in endometriosis. Endometrial primary cultures from women with and without endometriosis and endometrial cell lines were incubated with EA (50 and 100 μM) for 24 and 48 h. The results demonstrated that EA arrests an endometrial stromal cell cycle on the G2/M phase, after 48 h. In addition, 100 μM EA treatment significantly decreased ECC-1 cell migration at 20 h and T-HESC cell migration at 10 h and 20 h, while 50 μM EA significantly decreased T-HESC cell migration at 20 h. On the other hand, we proved that the treatment with EA for 24 h reduces T-HESC and ECC-1 adhesion to plastic. However, we did not find an effect of EA on cell proliferation. EA has an inhibitory effect on endometrial cell adhesion, migration and cell cycle progression in vitro. These highlight the idea to investigate natural compounds as novel and promising candidates for therapeutic treatment of endometriosis.
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Potential use of ellagic acid for endometriosis treatment: its effect on a human endometrial cell cycle, adhesion and migration Abstract Endometriosis is a common and challenging condition of reproductive-aged women that is defined as the presence of endometrial-like tissue outside the uterine cavity. Despite its prevalence, there is still no effective therapeutics; so we aim to evaluate the ellagic acid (EA) effect on the most relevant aspects that are known to be altered in endometriosis. Endometrial primary cultures from women with and without endometriosis and endometrial cell lines were incubated with EA (50 and 100 μM) for 24 and 48 h. The results demonstrated that EA arrests an endometrial stromal cell cycle on the G2/M phase, after 48 h. In addition, 100 μM EA treatment significantly decreased ECC-1 cell migration at 20 h and T-HESC cell migration at 10 h and 20 h, while 50 μM EA significantly decreased T-HESC cell migration at 20 h. On the other hand, we proved that the treatment with EA for 24 h reduces T-HESC and ECC-1 adhesion to plastic. However, we did not find an effect of EA on cell proliferation. EA has an inhibitory effect on endometrial cell adhesion, migration and cell cycle progression in vitro. These highlight the idea to investigate natural compounds as novel and promising candidates for therapeutic treatment of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Ellagic Acid Endometriosis Adult Cell Adhesion Cell Adhesion Cell Cycle Cell Cycle Cell Line Cell Line Cell Movement Cell Movement Ellagic Acid Ellagic Acid Endometriosis Endometrium Endometrium Female Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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