Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study

Iñaki Lete, Mendoza N, Nicolás Mendoza, de la Viuda E, Esther de la Viuda, Francisco Carmona
European journal of obstetrics, gynecology, and reproductive biology · 2018 · vol. 228 , pp. 221–224 · doi:10.1016/j.ejogrb.2018.07.002 · PMID:30007250 · W2882825046
Non-randomised trial OA: closed CC0 ⤵ 34 in-corpus citations
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This study investigated the effectiveness of an antioxidant preparation containing N-acetyl cysteine, alpha lipoic acid, and bromelain for treating pelvic pain associated with endometriosis.

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Abstract

OBJECTIVE: To assess the impact of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain on endometriosis-associated pelvic pain. STUDY DESIGN: Multicenter, open-label, non-comparative clinical trial in a representative sample of women with endometriosis-associated pelvic pain. RESULTS: In total, 398 patients with a mean age of 34.6 ± 7.2 years were treated with a combination of N-acetyl cysteine, alpha lipoic acid and bromelain for 6 months. At baseline, 92.7% of the patients had pain intensity > 4 on the visual analogue scale (VAS); at 3 months of treatment, this percentage decreased to 87.2% (p = 0.074) and at 6 months the percentage was 82.7% (p < 0.05). CONCLUSIONS: Women with endometriosis who wish to become pregnant and are treated with a preparation containing N-acetyl cysteine, alpha lipoic acid and bromelain experienced a significant improvement in endometriosis-associated pelvic pain and required lower intake of rescue analgesics.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Acetylcysteine Antioxidants Bromelains Endometriosis Pelvic Pain Thioctic Acid Acetylcysteine Acetylcysteine Adult Adult Antioxidants Antioxidants Bromelains Bromelains Drug Combinations Drug Combinations Endometriosis Endometriosis Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Cited by (38)

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