Female Infertility and Free Radicals: Potential Role in Endometriosis and Adhesions

Oxidative stress is widely implicated in various forms of reproduction failure. Postoperative adhesions and endometriosis are the two common conditions associated with female infertility with several similarities in their development and clinical behavior. The pathophysiology of both conditions involves peritoneal surface inflammation, tissue healing, and fibrogenesis, in which alterations in oxidative metabolism appear to be operational. Enhanced free radical generation and/or decreased scavenging have been shown in the endometriosis and postoperative adhesion tissues. Interventions targeting oxidative metabolism for the prevention and treatment of either condition have given mixed results. Studies utilizing contemporary methods may shed further light on the involvement of oxidative stress leading to development of more targeted therapies in these conditions. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

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Semin Reprod Med 26:313–321 Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2013 Springer Science+Business Media New York About this chapter Cite this chapter Alpay Savasan, Z. (2013). Female Infertility and Free Radicals: Potential Role in Endometriosis and Adhesions. In: Agarwal, A., Aziz, N., Rizk, B. (eds) Studies on Women's Health. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-041-0_16 Download citation DOI: https://doi.org/10.1007/978-1-62703-041-0_16 Published: Publisher Name: Humana Press, Totowa, NJ Print ISBN: 978-1-62703-040-3 Online ISBN: 978-1-62703-041-0 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)