Endometriosis stem cell sources and potential therapeutic targets: literature review and bioinformatics analysis

Zhe Jin, Yize Zhang, Zhang Y, Jingyi Li, Sidi Lv, Lv S, Zhang L, Lixia Zhang, Ying Feng
Regenerative medicine · 2021 · vol. 16(10) , pp. 949–962 · doi:10.2217/rme-2021-0039 · PMID:34585967 · W3204398847
Review OA: closed CC0 ⤵ 3 in-corpus citations
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This literature review and bioinformatics analysis summarizes the potential stem cell sources of endometriosis and predicts targeted miRNAs to identify novel therapeutic strategies for this disease.

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Abstract

The stem cell origin theory of endometriosis (EMS) is a significant area of new research but the sources of this have yet to be adequately summarized. Existing treatments for EMS are commonly associated with a high recurrence rate; consequently, there is an urgent need to develop new therapeutic measures for the future treatment of this disease from the view of stem cells and gene therapy. Recently, we described the evidence for the potential sources of EMS stem cells and other key molecules participating in the establishment of lesions, and predict the miRNAs that target these key genes via bioinformatics analysis for further research. This review highlights the origin of EMS stem cells and potential therapy targets.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Computational Biology Computational Biology Female Female Humans Humans Stem Cells Stem Cells

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (99)

Cited by (3)

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