[Endometriosis-associated ovarian cancers: pathogenesis and consequences on daily practice]

Bruno Borghese, B Borghese, Piétro Santulli, Santulli P, P Santulli, D Vaiman, Vaiman D, Daniel Vaiman, Alexandre J, J. Alexandre, Jérôme Alexandre, F Goldwasser, François Goldwasser, Goldwasser F, Chapron C, C. Chapron, Charles Chapron
Journal de gynecologie, obstetrique et biologie de la reproduction · 2013 · vol. 42(4) , pp. 325–333 · doi:10.1016/j.jgyn.2013.02.013 · PMID:23578493 · W2029105626
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Endometriosis, classified as a tumor-like lesion, is associated with an increased risk of Type 1 ovarian cancers, raising questions about screening and management despite unclear causality.

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Abstract

Endometriosis is considered as a tumor-like lesion under the World Health Organization (WHO) classification of ovarian tumors. Data from large cohort and case-control studies indicate that patients with a history of endometriosis have an increased risk of ovarian cancer. Recent findings suggest an association between endometriosis and the entire type 1 ovarian tumors group including clear-cell, endometrioid and low-grade serous carcinomas. However, current evidence is lacking to draw definitive conclusion whether this association represents causality or the sharing of common risk factors. Nevertheless, assumption that endometriosis could be a precursor of malignancy raises many issues about serial screening, surgical management and surveillance of endometriosis. Beyond these concerns, endometriosis-associated ovarian cancers seem to be a genuine clinical entity as regards clinicopathological features. In view of the high incidence of endometriosis (10 % of women of childbearing age), the low incidence of endometriosis-associated ovarian cancers and the psychological consequences for those women, systematic screening and surgical exploration seem very questionable in this context.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Neoplasms Professional Practice Professional Practice Cell Transformation, Neoplastic Cell Transformation, Neoplastic Cell Transformation, Neoplastic Disease Progression Disease Progression Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans Ovarian Neoplasms Ovarian Neoplasms

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (82)

Cited by (3)

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