CD10 immunohistochemical staining enhances the histological detection of endometriosis

Potlog-Nahari C, Clariss Potlog-Nahari, Clariss Potlog‐Nahari, Andrew L. Feldman, Stratton P, Pamela Stratton, Deloris E. Koziol, Koziol DE, James H. Segars, James Segars, Merino MJ, Maria J. Merino, Lynnette K. Nieman
Fertility and sterility · 2004 · vol. 82(1) , pp. 86–92 · doi:10.1016/j.fertnstert.2003.11.059 · PMID:15236994 · W2033978743
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CD10 immunohistochemistry improved the detection of endometriosis lesions, reclassifying 11 initially H&E-negative specimens and increasing the overall detection rate from 35% to 45%.

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Abstract

OBJECTIVE: To determine whether the use of CD10 immunohistochemistry in addition to hematoxylin and eosin (H&E) staining would increase the sensitivity of surgically suspected endometriosis lesions. DESIGN: Retrospective cohort study. SETTING: Tertiary care government research hospital. PATIENT(S): Thirty-one women with chronic pelvic pain. INTERVENTION(S): Immunohistochemical analysis for CD10 was performed on 108 possible endometriotic lesions and in the corresponding endometrial biopsy samples obtained during laparoscopy. When CD10 immunohistochemistry results were positive, the corresponding H&E section was reviewed to determine if the initial diagnosis should be revised. MAIN OUTCOME MEASURE(S): Histologic diagnosis of endometriosis by adjunctive use of CD10 immunohistochemistry in conjunction with H&E-stained specimens. RESULT(S): In endometrial stroma, CD10 was consistently present. Of the 70 specimens judged negative initially by H&E staining, CD10 staining led to the diagnosis of endometriosis in 11. The addition of CD10 immunohistochemistry detected more positive endometriosis lesions than H&E staining alone (45% vs. 35%). In three women with minimal endometriosis at surgery but initially negative histopathology, CD10 immunohistochemistry changed the histologic diagnosis to endometriosis. CONCLUSION(S): The adjunctive use of CD10 immunohistochemistry improves diagnostic sensitivity for endometriosis, especially for women with minimal disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Neprilysin Adult Adult Cohort Studies Cohort Studies Coloring Agents Coloring Agents Diagnosis, Differential Diagnosis, Differential Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Eosine Yellowish-(YS) Eosine Yellowish-(YS) Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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