Lynnette K. Nieman
ORCID: 0000-0003-0534-8025
· 34 papers in corpus
review
2022
PURPOSE OF REVIEW: This review is intended to provide perspective on the history of selective progesterone receptor modulators (SPRMs) and progesterone antagonists, their current availability, therapeutic promise and safety concerns. RECEN…
article
2020
To develop a model using individual and lesion characteristics to help surgeons choose lesions with a high probability of containing histologically-confirmed endometriosis.
2020
Postpartum depression (PPD) is a common complication following delivery, though evidence-based treatment options are limited. This study explores the feasibility and efficacy of outpatient PPD treatment with transdermal estradiol (TE). In a…
2019
BackgroundAutonomous ovarian activation with recurrent estrogen-producing cysts is a hallmark feature of the rare bone and endocrine disorder fibrous dysplasia/McCune-Albright syndrome. Precocious puberty in girls with McCune-Albright syndr…
article
2015
OBJECTIVE: To evaluate whether 6 months of raloxifene was effective in treatment of chronic pelvic pain in women with endometriosis. METHODS: Women with chronic pelvic pain and no endometriosis treatment for 6 months underwent lapa-roscopy …
article
2014
article
2011
Nuclear and cytoplasmic endometrial expression of Indian hedgehog increased from the late proliferative to mid and late secretory phases in 26 healthy volunteers compared with 30 women with endometriosis. The abnormal expression of Indian h…
article
2011
OBJECTIVE: To study whether pain location is related to lesion location in women with chronic pelvic pain and biopsy-proven endometriosis. METHODS: A secondary analysis was performed to compare self-reported pain location with recorded lapa…
2010
ObjectiveTo test potential contraceptive mechanisms of the selective P receptor modulator CDB-2914 in the early luteal phase.DesignProspective randomized clinical trial.SettingClinical research center.Patient(s)Fifty-six women with regular …
2010
ContextProgesterone is critical for secretory endometrial differentiation in women, but its downstream mediators are poorly understood.ObjectiveOur objective was to investigate endometrial expression of Indian Hedgehog (IHH) and genes invol…
article
2010
ObjectiveTo examine the prevalence of migraine in women with chronic pelvic pain with and without endometriosis.DesignProspective study of headache, pelvic pain, and quality of life before laparoscopic surgery for pelvic pain. Endometriosis…
other
2009
Reduced expression of biomarkers associated with the implantation window in women with endometriosis
OBJECTIVE: To evaluate the expression of biomarkers of implantation, glycodelin A (GdA), osteopontin (OPN), lysophosphatidic acid receptor 3 (LPA3), and HOXA10, in eutopic endometrium of women with and without endometriosis. DESIGN: Prospe…
article
2008
ObjectiveTo develop a model that uses individual and lesion characteristics to help surgeons choose lesions that have a high probability of containing histologically confirmed endometriosis.DesignSecondary analysis of prospectively collecte…
article
2008
OBJECTIVE: To evaluate whether 6 months of raloxifene was effective in treatment of chronic pelvic pain in women with endometriosis. METHODS: Women with chronic pelvic pain and no endometriosis treatment for 6 months underwent laparoscopy f…
other
2008
OBJECTIVE: To correlate histology with endometriosis characteristics. DESIGN: Secondary data analysis. SETTING: Government research hospital. PATIENT(S): One hundred thirty-three women with chronic pelvic pain and endometriosis who under…
article
2007
other
2006
OBJECTIVE: To evaluate the expression of estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), and breast cancer nuclear receptor auxiliary factor (Brx) in eutopic endometrium of normal women and women with endometriosis. DES…
article
2006
ObjectiveTo evaluate whether persistence of pelvic pain after excision of endometriosis was associated with adenomyosis as defined by a thickened uterine junctional zone (JZ) on magnetic resonance (MR) imaging.DesignProspective clinical tri…
article
2005
article
2004
ObjectiveTo determine whether the use of CD10 immunohistochemistry in addition to hematoxylin and eosin (H&E) staining would increase the sensitivity of surgically suspected endometriosis lesions.DesignRetrospective cohort study.SettingTert…
other
2004
OBJECTIVE: To determine whether urine VEGF is elevated in women with endometriosis. DESIGN: Prospective observational study. SETTING: Tertiary care government and private hospitals. PATIENT(S): During laparoscopy for pelvic pain or infer…
article
2003
CDB-2914 (17 alpha-acetoxy-11 beta-[4-N,N-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione) is a 19-norprogesterone derivative that acts as an antagonist in progesterone-responsive tissues. It binds to progesterone receptors A and B w…
article
2003
article
2003
ObjectiveTo evaluate the utility of fat-suppressed magnetic resonance imaging (MRI) in the diagnosis of endometriosis.DesignA prospective clinical trial.SettingA government research hospital.Patient(s)Forty-eight women with pelvic pain.Inte…
rct
2003
BACKGROUND: Progesterone receptor modulators have potential therapeutic use in progesterone-dependent conditions such as endometriosis, fibroids and induction of labour. The synthetic steroid CDB-2914 binds to the progesterone and glucocort…