Important role of collective cell migration and nerve fiber density in the development of deep nodular endometriosis

Renán Orellana, Renan Orellana, Javier García-Solares, García-Solares J, Jacques Donnez, Donnez J, Van Kerk O, Olivier Van Kerk, Marie-Madeleine Dolmans, Dolmans MM, Marie‐Madeleine Dolmans, Olivier Donnez, Donnez O
Fertility and sterility · 2017 · vol. 107(4) , pp. 987–995.e5 · doi:10.1016/j.fertnstert.2017.01.005 · PMID:28238494 · W2590716388
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This paper investigated the roles of collective cell migration and nerve fiber density in the development of deep nodular endometriosis.

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Abstract

OBJECTIVE: To evaluate deep nodular endometriotic lesions induced in baboons over 12 months and analyze collective cell migration and nerve fiber density. DESIGN: Morphologic and immunohistochemical analysis of endometriotic lesions induced in baboons over the course of 1 year. SETTING: Academic research unit. ANIMAL(S): Three female baboons (Papio anubis). INTERVENTION(S): Recovery of induced deep nodular endometriotic nodules from baboons. MAIN OUTCOME MEASURE(S): Evaluation of the morphology of glands by analysis of the center of lesions and the invasion front; immunohistochemical staining with Ki67, E-cadherin, and β-catenin for investigation of mitotic activity and cell-cell junctions, and with protein gene product 9.5 and nerve growth factor (NGF) for study of nerve fiber density (NFD). RESULT(S): All (100%) of the lesions were invasive 1 year after induction, compared with 42.29% after 6 months. Glands from the invasion front showed significantly reduced thickness but significantly higher mitotic activity. E-Cadherin and β-catenin expression were similar between the center and front. NFD was significantly higher in lesions induced after 1 year than after 6 months, and NGF expression was significantly lower in 1-year lesions than in 6-month lesions. CONCLUSION(S): Nodular endometriotic lesions induced in the baboon model were found to be significantly more invasive and innervated after 12 months than after 6 months. The invasive phenotype was highly expressed in glands at the invasion front, and our study suggests that nerve fibers play a role in the development of lesions as observed in women.

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Condition tags

endometriosis

MeSH descriptors

Cell Movement Cell Movement Endometriosis Endometrium Nerve Fibers Animals Animals beta Catenin beta Catenin beta Catenin Biomarkers Biomarkers Biomarkers Cadherins Cadherins Cadherins Disease Models, Animal Disease Models, Animal Endometriosis Endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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