The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue

Biyik I, Ismail Biyik, İsmail Bıyık, Üzeyir Kalkan, Uzeyir Kalkan, Simsek S, Sercan Simsek, Sercan Şimşek
Taiwanese journal of obstetrics & gynecology · 2021 · vol. 60(6) , pp. 1059–1065 · doi:10.1016/j.tjog.2021.09.017 · PMID:34794738 · W3212960830
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Deep infiltrating endometriosis tissue showed significantly lower T-cadherin, E-cadherin, progesterone receptor, and estrogen receptor expression compared to ovarian endometrioma and normal endometrial tissues.

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Abstract

OBJECTIVE: To compare the T-cadherin, E-cadherin, PR and ER staining levels of deep infiltrating endometriosis (DIE) tissue, ovarian endometriomas and normal endometrial tissues. MATERIALS AND METHODS: DIE tissue of 24 cases, endometrioma of 30 cases and normal endometrial tissues of 30 cases were examined. T-cadherin, E-cadherin, ER-α and PR-α staining levels of DIE, endometrioma tissues and endometrial tissues were compared immunohistochemically. H-score was calculated to compare the expression of T-cadherin, E-cadherin, ER-α, PR-α in IHC staining based on the percentage of cells stained at each intensity level. RESULTS: T-cadherin, E-cadherin, ER and PR H-score were found lowest in DIE tissue and the highest in endometrial tissue (p < 0.0001, <0.0001, <0.0001 and < 0.0001, respectively). In correlation analysis, a positive correlation was found between T-cadherin, E-cadherin, PR and ER H-score (p 0.05). CONCLUSION: T-cadherin, E-cadherin, ER and PR H-score were found lowest in DIE tissue, the highest in endometrium tissue. The finding of lower expression of PR-α in endometriotic nodule in our study may be related to decrease in progesterone effect which could not inhibit the decrease in the expression of T-cadherin and E-cadherin, thus the invasiveness of DIE tissue. These findings suggest that DIE tissue and ovarian endometrioma tissues have a different biology.

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Outcome instruments

VAS-pain

Condition tags

endometriosisdie_deep_infiltratingendometriomadysmenorrheadyspareunia

MeSH descriptors

Cadherins Endometriosis Endometrium Receptors, Estrogen Receptors, Progesterone Adult Cadherins Endometriosis Endometrium Estrogen Receptor alpha Female Humans Receptors, Estrogen Receptors, Progesterone

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