Decreased expression of the decoy interleukin-1 receptor type II in human endometriosis

Akoum A, A Akoum, Ali Akoum, Christine Jolicoeur, C Jolicoeur, Jolicoeur C, Abdelaziz Kharfi, Kharfi A, A Kharfi, Marie Aubé, M Aubé, Aubé M
The American Journal of Pathology · 2001 · vol. 158(2) , pp. 481–489 · doi:10.1016/s0002-9440(10)63990-9 · PMID:11159185 · PMC1850310 · W2080802473
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This study investigated the expression of the decoy interleukin-1 receptor type II (IL-1RII) in human endometriosis and found it to be decreased in affected tissues.

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Abstract

Many of the biological changes occurring in the endometrium during the menstrual cycle bear a striking resemblance to those associated with inflammatory and reparative processes. Hence, it would not be surprising to find that cytokines known for their pro-inflammatory properties, such as interleukin-1 (IL-1), could play a key role in the physiology of this tissue and that their action would be tightly controlled by local mechanisms. In the present study, immunohistochemical and Western blot analyses show that in normal women (n = 39), the endometrial tissue expresses, in a cycle-dependent manner, the IL-1 receptor type II (IL-1RII), a molecule of which the only biological property known to date is that of capturing IL-1, inhibiting thereby its binding to the functional type I IL-1 receptor. IL-RII immunostaining was particularly intense within the lumen of the glands and at the apical side of surface epithelium. Interestingly, the intensity of staining was markedly less pronounced in the endometrium of women with endometriosis (n = 54), a disease believed to arise from the abnormal development of endometrial tissue outside the uterus, especially in the early stages of the disease (stages I and II). This study is the first to show the local expression in endometrial tissue of IL-1RII, a potent and specific down-regulator of IL-1 action and its decreased expression in women suffering from endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Receptors, Interleukin-1 Adult Adult Blotting, Western Blotting, Western Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female Female Humans Humans Immunohistochemistry Immunohistochemistry Receptors, Interleukin-1

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (38)

Cited by (23)

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