Human uterine endometrium and endometriotic tissue transplanted into nude mice. Morphologic effects of various steroid hormones

Bergqvist A, Agneta Bergqvist, A Bergqvist, Sten Jeppsson, S Jeppsson, Jeppsson S, Stig Kullander, Kullander S, S Kullander, Ljungberg O, O Ljungberg, Otto Ljungberg
The American Journal of Pathology · 1985 · vol. 121(2) , pp. 337–41 · PMID:4061568 · PMC1888054 · W1552188658
Lab / animal OA: green CC0 ⤵ 53 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Human uterine endometrium and endometriotic tissue transplanted into nude mice showed similar histologic changes in response to various steroid hormones, suggesting environmental factors influence their differences.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

In a study of the morphologic effects of various steroid hormones on human uterine endometrium and endometriotic tissue, specimens from 6 women were transplanted subcutaneously into 24 nude mice. In each case, specimens collected simultaneously were transplanted to 4 mice, endometrium to one lateral abdominal wall and endometriotic tissue to the other. All mice were given polyestradiol phosphate subcutaneously the first day after operation. After a 2-week interval, of each 4 mice, 1 mouse was given polyestradiol phosphate, 1 medroxyprogesterone acetate, 1 danazol, and 1 no further injections. This treatment continued for 8 weeks, after which the mice were killed and the grafts extirpated. Histologic changes in the grafts varied according to the treatment schedule but were very similar in both types of tissue. Our findings suggest that histologic differences between endometrium and endometriotic tissue seen under natural conditions may, at least partly, be due to variations in environmental factors.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Hormones Uterus Adult Adult Animals Animals Danazol Danazol Danazol Endometriosis Endometriosis Endometrium Endometrium Estradiol Estradiol Estradiol Estradiol Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (14)

Cited by (50)

Source provenance

europepmc
last seen: 2026-10-18T09:30:06.152893+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:50:23.673636+00:00
License: CC0 · commercial use OK