PDCD4 suppresses proliferation, migration, and invasion of endometrial cells by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway†

Li Y, Yue Li, Xiaoyan Wang, Wang X, Xishuang Wang, Wan L, Lu Wan, Yanping Liu, Liu Y, Shi Y, Yongyu Shi, Lining Zhang, Zhang L, Fang Z, Zhenghui Fang, Wei Z, Zengtao Wei
Biology of reproduction · 2018 · vol. 99(2) , pp. 360–372 · doi:10.1093/biolre/ioy052 · PMID:29912279 · W2809179051
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Programmed cell death 4 (PDCD4) was downregulated in endometriosis patients and suppressed endometrial cell proliferation, migration, and invasion by inhibiting autophagy and the NF-κB/MMP2/MMP9 pathway.

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Abstract

Endometriosis (EM) is a kind of estrogen-dependent disease in reproductive-age women. Ovarian EM is the most common type. Although EM is a benign disease, it shares many similar features with cancers. Programmed cell death 4 (PDCD4), a newly identified tumor suppressor, plays an important role in inhibiting tumorigenesis and tumor progression at the transcriptional and translational levels. To explore the roles of PDCD4 in EM, we detected the expression of PDCD4 in control endometrium and eutopic/ectopic endometrium of ovarian EM patients, and analyzed the effects of PDCD4 on the biological behaviors of endometrial cell lines and primary endometrial cells. The results demonstrated that PDCD4 was downregulated in eutopic and ectopic endometrium of EM patients compared with control endometrium. PDCD4 effectively inhibited the proliferation and colony-forming ability of endometrial cells maybe by inhibiting cell autophagy. In addition, PDCD4 also suppressed the migration and invasion ability of endometrial cells, the mechanism may be related to NF-κB/MMP2/MMP9 signal pathway. Taken together, these results suggest that PDCD4 could be involved in the pathogenesis of EM, and provide a novel approach to target the aberrant PDCD4 expression in EM.

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Condition tags

endometriosis

MeSH descriptors

Apoptosis Regulatory Proteins Autophagy Cell Movement Cell Proliferation Endometriosis Endometrium RNA-Binding Proteins Signal Transduction Apoptosis Apoptosis Apoptosis Regulatory Proteins Apoptosis Regulatory Proteins Autophagy Cell Cycle Cell Cycle Cell Line Cell Movement Cell Proliferation Down-Regulation Endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (18)

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