N-myc Downstream-Regulated Gene 1 and Endometriosis: A Minireview

Tong Lou, Chongdong Liu, Zhenyu Zhang
Critical reviews in eukaryotic gene expression · 2017 · vol. 27(4) , pp. 341–345 · doi:10.1615/critreveukaryotgeneexpr.2017020516 · PMID:29283328 · W2765934022
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review examines N-myc downstream-regulated gene 1's (NDRG1) role in endometriosis, focusing on its potential function via signaling pathways and areas needing further research.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This minireview examines N-myc downstream-regulated gene 1 (NDRG1), originally viewed as differentiation-related but now described as influencing tumor-cell proliferation, migration, invasion, and vascularization, with most studies characterizing it as a tumor suppressor. The authors summarize evidence that NDRG1 is expressed in normal endometrium (higher in the secretory phase) and note that NDRG1 was first identified as an inhibitor of signaling pathways linked to endometriosis, proposing that its regulation of endometriosis involves multiple pathways. A key caveat is that the paper emphasizes assumed or potential functions and calls for additional research to define NDRG1’s role more clearly. This paper is centrally about endometriosis — it is a minireview specifically focused on the relationship between NDRG1 and endometriosis signaling/pathway regulation.

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Abstract

NDRG1 (N-myc downstream-regulated gene 1) was previously considered to be a differentiation-related gene. However, many other functions of NDRG1 have since been identified, including proliferation, migration, invasion, and vascularization of tumor cells. Currently regarded as a tumor suppressor in most studies, NDRG1 is abundant in prostate, brain, kidney, placental, and intestinal tissues. It is expressed in normal endometrium, with higher expression occurring in the secretory phase. NDRG1 was first identified as an inhibitor of signaling pathways associated with the pathology of endometriosis. The NDRG1 protein regulation of endometriosis is assumed to be associated with several important pathways. This review summarizes the relationship between NDRG1 and endometriosis, focusing on the potential function of NDRG1 in endometriosis through signaling pathways and discusses the additional research that is required for future studies.
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Critical Reviews™ in Eukaryotic Gene Expression Published 8 issues per year ISSN Print: 1045-4403 ISSN Online: 2162-6502 N-myc Downstream-Regulated Gene 1 and Endometriosis: A Minireview ABSTRACT NDRG1 (N-myc downstream-regulated gene 1) was previously considered to be a differentiation-related gene. However, many other functions of NDRG1 have since been identified, including proliferation, migration, invasion, and vascularization of tumor cells. Currently regarded as a tumor suppressor in most studies, NDRG1 is abundant in prostate, brain, kidney, placental, and intestinal tissues. It is expressed in normal endometrium, with higher expression occurring in the secretory phase. NDRG1 was first identified as an inhibitor of signaling pathways associated with the pathology of endometriosis. The NDRG1 protein regulation of endometriosis is assumed to be associated with several important pathways. This review summarizes the relationship between NDRG1 and endometriosis, focusing on the potential function of NDRG1 in endometriosis through signaling pathways and discusses the additional research that is required for future studies. - Li Yue, Wang Xiaoyan, Wang Xishuang, Wan Lu, Liu Yanping, Shi Yongyu, Zhang Lining, Fang Zhenghui, Wei Zengtao, PDCD4 suppresses proliferation, migration, and invasion of endometrial cells by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway†, Biology of Reproduction, 99, 2, 2018. Crossref - Meng Nan, Yang Qian, He Yaping, Gu Wen‐Wen, Gu Yan, Zhen Xing‐Xing, Wang Jianmei, Zhang Xuan, Sun Zhao‐Gui, Wang Jian, Decreased NDRG1 expression is associated with pregnancy loss in mice and attenuates the in vitro decidualization of endometrial stromal cells, Molecular Reproduction and Development, 86, 9, 2019. Crossref - Lou Tong, Liu Chongdong, Qu Hong, Zhang Zhiqiang, Wang Shuzhen, Zhuang Huiyu, FOXA1 can be modulated by HDAC3 in the progression of epithelial ovarian carcinoma, Journal of Translational Medicine, 20, 1, 2022. Crossref

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Condition tags

endometriosis

MeSH descriptors

Cell Cycle Proteins Endometriosis Intracellular Signaling Peptides and Proteins Cell Cycle Proteins Endometriosis Female Gene Expression Regulation, Neoplastic Gene Expression Regulation, Neoplastic Humans Intracellular Signaling Peptides and Proteins N-myc Downstream-Regulated Gene 1 Protein Signal Transduction Signal Transduction

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