A new therapy for pelvic endometriosis and uterine adenomyosis: local effect of vaginal and intrauterine danazol application

Igarashi M, Masao Igarashi, M Igarashi
Asia-Oceania journal of obstetrics and gynaecology · 1990 · vol. 16(1) , pp. 1–12 · doi:10.1111/j.1447-0756.1990.tb00207.x · PMID:2344304 · W2053567123
Non-randomised trial OA: closed CC0 ⤵ 42 in-corpus citations
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Local vaginal and intrauterine danazol application reduced pelvic endometriosis, uterine adenomyosis size, and induced pregnancy without inhibiting ovulation, indicating a direct action on endometriotic cells.

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Abstract

In order to investigate the effect of the local direct action of danazol upon endometriosis, intravaginal and intrauterine application were tried. A vaginal danazol ring containing 2 g to 3.5 g danazol not only reduced both dysmenorrhea and the extent of pelvic endometriosis in all 35 infertile women, but also resulted in conception in 13 out of 35 infertile women while the vaginal ring was in place. Uterine adenomyosis usually fails to respond to oral danazol therapy, but an intrauterine device containing 175 mg of danazol was effective in reducing the size of the uterus and in inducing pregnancy in 66.6% cases. It is noteworthy that this vaginal or intrauterine danazol therapy did not inhibit ovulation, but still effected atrophy of endometriosis and aided in the establishment of pregnancy. These results clearly demonstrate that the main mode of action of danazol is its direct action on endometriotic cells.

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Condition tags

endometriosisadenomyosisdysmenorrhea

MeSH descriptors

Danazol Endometriosis Pregnadienes Uterine Neoplasms Administration, Intravaginal Administration, Intravaginal Adult Adult Danazol Danazol Endometriosis Endometriosis Female Female Humans Humans Intrauterine Devices, Medicated Intrauterine Devices, Medicated Pregnadienes Pregnadienes

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (10)

Cited by (42)

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