Differential expression of IGF-I and IGF-II in eutopic and ectopic endometria of women with endometriosis and in women without endometriosis

Sbracia M, M Sbracia, Marco Sbracia, E. Zupi, Zupi E, Fabio Scarpellini, Alo P, Errico Zupi, P Alo, Claudio Manna, Manna C, C Manna, Daniela Marconi, Marconi D, D Marconi, F Scarpellini, Carlo Romaninï, Scarpellini F, Piero Alò, J A Grasso, Grasso JA, Ugo Di Tondo, U Di Tondo, Di Tondo U, Jennifer Grasso, Romanini C, C Romanini
American journal of reproductive immunology (New York, N.Y. : 1989) · 1997 · vol. 37(4) , pp. 326–329 · doi:10.1111/j.1600-0897.1997.tb00238.x · PMID:9161641 · W2081288455
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This study found altered expression of IGF-I and IGF-II in eutopic and ectopic endometriotic tissues compared to controls, suggesting dysregulation of cell proliferation and differentiation mechanisms in endometriosis.

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Abstract

PROBLEM: Factors regulating the development, growth, and differentiation of endometrial cells of endometriotic lesions are poorly understood. To investigate the paracrine-autocrine regulation of ectopic endometrial cell growth, the expression of IGF-I and IGF-II were studied. METHOD: Tissue specimens of eutopic and ectopic endometria were obtained from eight patients with endometriosis at laparoscopy and from the endometria of 14 women without endometriosis as controls. They were tested for the expression of IGF-I and IGF-II by immunohistochemical analysis. RESULTS: Immunohistochemical study for IGF-I in controls showed a more intense staining during the proliferative phase both in stromal and epithelial cells. In eutopic endometria of women with endometriosis a reduction in the staining was observed, whereas in epithelial cells of fibrotic peritoneal adhesions an intense immunostaining for IGF-I was observed. Immunohistochemical study of IGF-II in controls showed a more intense staining during secretory phase both in stromal and epithelial cells. In eutopic endometria of women with endometriosis, a reduction in the staining was observed, whereas in epithelial cells of fibrotic peritoneal adhesions an intense immunostaining for IGF-I was observed. Immunohistochemical study of IGF-II in controls showed a more intense staining during secretory phase both in stromal and epithelial cells. In eutopic endometria of women with endometriosis, a reduction in the staining was observed, whereas in epithelial cells of ovarian lesions and fibrotic peritoneal adhesions, no immunostaining for IGF-II was observed. CONCLUSIONS: In endometriosis there is an alteration of mechanisms regulating cell proliferation and differentiation.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Insulin-Like Growth Factor I Insulin-Like Growth Factor II Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Epithelium Epithelium Epithelium Female Female Humans Humans Immunohistochemistry Immunohistochemistry Insulin-Like Growth Factor I

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