Serum and peritoneal CA-125 levels as diagnostic test for endometriosis

Colacurci N, Nicola Colacurci, N Colacurci, Nicola Fortunato, Fortunato N, N Fortunato, P De Franciscis, Pasquale De Franciscis, Fratta M, M Fratta, Mario Fratta, Michèle Cioffi, M Cioffi, Zarcone R, Roberto Zarcone, R Zarcone, A Cardone, Cardone A, Antonio Cardone
European journal of obstetrics, gynecology, and reproductive biology · 1996 · vol. 66(1) , pp. 41–43 · doi:10.1016/0301-2115(95)02372-0 · PMID:8735757 · W2011834278
Diagnostic accuracy OA: closed CC0 ⤵ 26 in-corpus citations
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This study evaluated serum and peritoneal CA-125 levels as a diagnostic marker for endometriosis in women.

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Abstract

OBJECTIVE: To evaluate the clinical utility of CA-125 in the diagnosis of endometriosis and to compare the sensitivity of the serum and the peritoneal test as indicator of disease. STUDY DESIGN: Peritoneal fluid was obtained at laparoscopy. The quantitative determination of CA-125 in serum and in peritoneal fluid was performed by IRMA-mat CA-125 'two-step method', a two-site immunoradiometric assay, using 35 and 60 U/ml as cutoff. SETTING: Second Department of Gynecology and Obstetrics, Second University of Naples, Italy. PARTICIPANTS: A total of 26 women infertile undergoing diagnostic laparoscopy that exhibited endometriosis in 14 patients, normal pelvis in 12 patients (control group). INTERVENTIONS: None. RESULTS: CA-125 levels in peritoneal fluid were higher than those found in serum and were significantly elevated (P < 0.05), when compared with the control group, both in women with endometriosis stage I-II and stage III-IV. In serum, CA-125 levels increased only in advanced stage of endometriosis. CONCLUSIONS: Levels of CA-125 in peritoneal fluid seem to be a more sensitive indicator of disease than serum levels (0.86 vs. 0.36), especially in early stage endometriosis (0.80 vs. 0.20) which tends to be overlooked by the CA-125 serum test.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid CA-125 Antigen Endometriosis Ascitic Fluid Ascitic Fluid CA-125 Antigen CA-125 Antigen CA-125 Antigen Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometriosis Female Female Humans Humans Predictive Value of Tests Predictive Value of Tests Reproducibility of Results

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Cited by (26)

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