Serum- und Urinmarker als diagnostische Tests für Endometriose

Zusammenfassung Ein diagnostischer Test für Endometriose sollte eine hohe Sensitivität und Spezifität sowie einen hohen positiven und negativen prädiktiven Vorhersagewert haben. Er sollte reproduzierbar sein sowie geringe Kosten verursachen. Für die Patientin wäre es außerdem wünschenswert, wenn ein solcher Test nichtinvasiv und schmerzlos wäre. Mithilfe eines Endometriosetests sollte nicht nur die Erstdiagnose gestellt, sondern auch der Erfolg einer medikamentösen Therapie gemessen werden können. Dies wäre insbesondere für das Monitoring klinischer Studien mit neuen Medikamenten von Bedeutung. In der vorliegenden Übersichtsarbeit werden die aussichtsreichsten Einzel- oder Kombinationstests aus Blut- und Urinproben vorgestellt und ihre Sensitivität und Spezifität verglichen. Abstract A diagnostic test for endometriosis should exhibit high sensitivity and specificity as well as positive and negative predictive values. The test should be reproducible and have low costs. In addition patients would prefer a non-invasive and painless test. By means of this test it should be possible to achieve the first diagnosis of endometriosis as well as a measure of the success of a medicinal therapy of endometriosis. This would also be very important for the monitoring of clinical studies with new drugs. In this review article the most promising studies on single or combined tests on blood and urine samples are presented and the sensitivity and specificity are compared. Similar content being viewed by others Literatur Velebil P, Wingo PA, Xia Z et al (1995) Rate of hospitalization for gynecologic disorders among reproductive-age women in the United States. Obstet Gynecol 86:764–769 Eskenazi B, Warner ML (1997) Epidemiology of endometriosis. Obstet Gynecol Clin North Am 24:235–258 Mahmood TA, Templeton A (1991) Prevalence and genesis of endometriosis. 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