CA-125 in peritoneal fluid from patients with nonmalignant gynecologic disorders.
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Peritoneal fluid CA-125 levels were elevated in patients with benign gynecologic disorders compared to controls, but serum levels did not correlate and were not useful for diagnosis.
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Abstract
To assess the diagnostic value of measuring CA-125 levels in peritoneal fluid from women with nonmalignant gynecologic disorders, we determined CA-125 levels in peritoneal fluid and in serum collected simultaneously from 46 women undergoing gynecologic surgery. Patients with benign ovarian disease, non-ovarian gynecologic pathology and severe endometriosis had, on average, higher CA-125 levels in peritoneal fluid than did patients with a normal pelvis and those with mild endometriosis. There was no obvious correlation between peritoneal fluid and serum levels of CA-125. Our data show that (1) measurement of serum CA-125 levels is not useful for distinguishing between different benign gynecologic disorders, and (2) levels of CA-125 in peritoneal fluid in benign gynecologic disorders are comparable to the reported lower range of levels observed in women with intraperitoneal malignancies.
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Cited by (4)
- The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis 1998
- Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis 2016
- Interleukin-6 and other soluble factors in peritoneal fluid and endometriomas and their relation to pain and aromatase expression 2010
- Serum and peritoneal CA-125 levels as diagnostic test for endometriosis 1996
Cited by (4)
- Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis 2016
- Interleukin-6 and other soluble factors in peritoneal fluid and endometriomas and their relation to pain and aromatase expression 2010
- The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis 1998
- Serum and peritoneal CA-125 levels as diagnostic test for endometriosis 1996
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- pubmed
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