Immunologic aspects of human endometriosis

R W Steele, Russell W. Steele, Steele RW, W P Dmowski, Dmowski WP, W. Paul Dmowski, D J Marmer, Daniel J. Marmer, Marmer DJ
American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction · 1984 · vol. 6(1) , pp. 33–36 · doi:10.1111/j.1600-0897.1984.tb00106.x · PMID:6476182 · W2074353361
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This study found that women with endometriosis had significantly reduced T-lymphocyte-mediated cytotoxicity to autologous endometrial cells, while nonspecific immune parameters were comparable to controls.

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Abstract

General and specific immune function were examined in women with endometriosis. Nonspecific parameters included total leukocyte and differential counts, quantitative immunoglobulin (IgG, IgA, and IgM) determinations, total hemolytic complement, C3, C4, mitogen-induced lymphocyte stimulation, and human leukocyte antigen (HLA) typing; no differences were observed when data were compared to age-matched controls without endometriosis. In contrast, the specific immune response T-lymphocyte-mediated cytotoxicity to autologous endometrial cells was significantly reduced (P less than 0.01) in women with endometriosis. When results from patients were analyzed according to clinical severity of endometriosis, even more striking immunologic alterations were delineated. In addition, lymphocyte stimulation responses to autologous endometrial antigen were lower in patients with severe or moderate disease, approaching statistical significance (P = 0.18 and 0.12, respectively). These studies suggest an immunologic basis for development of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Immunity, Cellular Immunity, Cellular Pelvic Neoplasms Adult Adult Autoantigens Autoantigens Autoantigens Cytotoxicity, Immunologic Cytotoxicity, Immunologic Endometriosis Endometriosis Female Female Humans Humans Infertility, Female Infertility, Female Infertility, Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (15)

Cited by (50)

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