Endometriosis is associated with aberrant metabolite profiles in plasma

Sophia Letsiou, Peterse DP, Dirkje P. Peterse, Amelie Fassbender, Fassbender A, Margriet M Hendriks, Margriet M. W. B. Hendriks, Hendriks MM, van den Broek NJ, Niels J. van den Broek, Rudolf Berger, Berger R, Dorien F O, O DF, Vanhie A, Arne Vanhie, Alexandra Vodolazkaia, Vodolazkaia A, Van Langendonckt A, Anne Van Langendonckt, Donnez J, Jacques Donnez, Harms AC, Amy C. Harms, Rob J. Vreeken, Groothuis PG, Patrick G. Groothuis, Dolmans MM, Marie‐Madeleine Dolmans, Marie-Madeleine Dolmans, Brenkman AB, Arjan B. Brenkman, Thomas M D'Hooghe, D'Hooghe TM, Thomas D’Hooghe
Fertility and sterility · 2017 · vol. 107(3) , pp. 699–706.e6 · doi:10.1016/j.fertnstert.2016.12.032 · PMID:28259259 · W2592878994
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This study identified altered metabolite profiles in the plasma of individuals with endometriosis compared to controls, suggesting potential biomarkers for the condition.

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Abstract

OBJECTIVE: To identify metabolites that are associated with and predict the presence of endometriosis. DESIGN: Metabolomics study using state-of-the-art mass spectrometry approaches. SETTING: University hospital and universities. PATIENT(S): Twenty-five women with laparoscopically confirmed endometriosis (cases) and 19 women with laparoscopically documented absence of endometriosis (controls). None of the women included in this study had received oral contraception or GnRH agonists for a minimum of 1 month before blood collection. INTERVENTION(S): Plasma collection. MAIN OUTCOME MEASURE(S): Metabolite profiles were generated and interrogated using multiple mass spectrometry methods, that is, high performance liquid chromatography coupled with negative mode electrospray ionization tandem mass spectrometry, UPLC-MS/MS, and ultra performance liquid chromatography-electroSpray ionization-quadrupole time-of-flight (UPLC-ESI-Q-TOF). Metabolite groups investigated included phospholipids, glycerophospholipids, ether-phospholipids, cholesterol-esters, triacylglycerol, sphingolipids, free fatty acids, steroids, eicosanoids, and acylcarnitines. RESULT(S): A panel of acylcarnitines predicted the presence of endometriosis with 88.9% specificity and 81.5% sensitivity in human plasma, with a positive predictive value of 75%. However, due to data limitations the outcome of the receiver operating characteristic curve analysis was not significant. CONCLUSION(S): A diagnostic model based on acylcarnitines has the potential to predict the presence and stage of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Carnitine Endometriosis Lipids Metabolomics Metabolomics Metabolomics Adult Adult Area Under Curve Area Under Curve Belgium Belgium Biomarkers Biomarkers Biomarkers Carnitine Carnitine Carnitine Case-Control Studies Case-Control Studies

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (41)

Cited by (50)

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