Endometriosis-associated infertility: double intrauterine insemination improves fecundity in patients positive for antiendometrial antibodies

Subit M, Michael Subit, Gantt P, Pickens Gantt, Pickens A. Gantt, Mike Broce, Broce M, Dara J Seybold, Seybold DJ, Dara Seybold, Randall G, Gary W. Randall, Gary Randall
American journal of reproductive immunology (New York, N.Y. : 1989) · 2011 · vol. 66(2) , pp. 100–107 · doi:10.1111/j.1600-0897.2010.00973.x · PMID:21244562 · W1600720746
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This study found that double intrauterine insemination improved fecundity in women with endometriosis-associated infertility who were positive for antiendometrial antibodies.

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Abstract

PROBLEM: Prospective registry study evaluating effects of endometriosis (E) and serum antiendometrial antibodies (AEA) on fecundity in intrauterine insemination (IUI) cycles. METHOD OF STUDY: AEA assays on 572 consecutive women receiving 969 single and 274 double IUI cycles. Logistic regression was utilized. RESULTS: Fecundity was 11.5% (143/1243 cycles). Double IUI improved fecundity with significance achieved in certain study groups. Compared to the AEA- subgroup, all study groups except for the E+ AEA- group had significantly lower fecundity. Two study groups receiving double IUI had significantly increased fecundity, E- AEA+ (OR: 5.1, CI: 1.1-22.7, P=0.032) and E+ AEA+ (OR: 4.1, CI: 1.2-14.0, P=0.025) and significant predictors of pregnancy (E- AEA+, OR: 7.8, CI: 1.7-36.2, P=0.009 and E+ AEA+, OR: 4.2, CI: 1.2-15.1, P=0.026). CONCLUSION: Double IUI improves fecundity in AEA+ patients. E-associated infertility is better diagnosed by the AEA assay than by surgery. Double IUI should be attempted prior to assisted reproductive technologies in AEA+ patients with normal fallopian tubes.

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Condition tags

endometriosisinfertility

MeSH descriptors

Autoantibodies Endometriosis Endometrium Fertility Infertility, Female Insemination, Artificial Adult Adult Autoantibodies Autoantibodies Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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