Modifiable life style factors and risk for incident endometriosis

Rachael Hemmert, Karen C. Schliep, Sydney Willis, Sydney K. Willis, Charles Matthew Peterson, Charles M. Peterson, Germaine Buck Louis, Germaine M. Buck Louis, Kristina Allen-Brady, Kristina Allen‐Brady, Sara E Simonsen, Joseph B. Stanford, Jiyoung Byun, Ken R Smith
Paediatric and perinatal epidemiology · 2018 · vol. 33(1) , pp. 19–25 · doi:10.1111/ppe.12516 · PMID:30307628 · PMC6353682 · W2914060917
article OA: closed CC0 ⤵ 54 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study assessed lifestyle factors before laparoscopy and found no associations between alcohol, caffeine, smoking, or physical activity and endometriosis risk, though sitting time showed a trend toward increased risk.

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Abstract

BACKGROUND: Caffeine, alcohol, smoking and physical activity are known to alter sex steroid synthesis, which may affect hormone-dependent gynaecologic disease risk, such as endometriosis; however, few studies have assessed life style factors prior to endometriosis diagnosis. METHODS: Four hundred and seventy three women, ages 18-44 years, underwent laparoscopy or laparotomy, regardless of clinical indication, at 14 clinic sites, 2007-2009. Women with prior surgically confirmed endometriosis were excluded. Life style factors were assessed prior to surgery. Adjusted risk ratios (RR) of endometriosis by caffeine, alcohol, smoking (serum cotinine), and physical activity were estimated, adjusting for age, marital status, education, race/ethnicity, age at menarche, gravidity, BMI, study site, and other life style factors. RESULTS: There were no associations between women with endometriosis and alcohol consumption (RR 0.9, 95% CI 0.7, 1.3), caffeine consumption (RR 1.1, 95% CI 0.8, 1.5), or smoking (serum cotinine <10 vs ≥10 ng/mL; RR 1.0, 95% CI 0.7, 1.6). Similar null findings were found between endometriosis and weekly occurrences of physical activity and total walking, moderate, and vigorous activity; a modest trend was found between total daily sitting time and increased endometriosis risk. CONCLUSIONS: This study, which is unique in its capture of life style exposures prior to incident endometriosis diagnosis, largely found no association between alcohol, caffeine, smoking, and physical activity and risk of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Risk Reduction Behavior Adolescent Adult Alcohol Drinking Alcohol Drinking Caffeine Caffeine Cotinine Cotinine Endometriosis Endometriosis Exercise Female Humans Incidence Marital Status Odds Ratio Risk Factors Smoking

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